HIOC
外观
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臨床資料 | |
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ATC碼 |
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识别信息 | |
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CAS号 | 314054-36-9 |
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CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C16H19N3O3 |
摩尔质量 | 301.35 g·mol−1 |
3D模型(JSmol) | |
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HIOC是一种含氮有机化合物,化学式C
16H
19N
3O
3,属于N-乙酰血清素(NAS)衍生物,可作为脑源性神经营养因子受体TrkB的小分子激动剂[1][2][3]。
参考文献
[编辑]- ^ Longo FM, Massa SM. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nature Reviews. Drug Discovery. July 2013, 12 (7): 507–525. PMID 23977697. S2CID 33597483. doi:10.1038/nrd4024.
- ^ Iuvone PM, Boatright JH, Tosini G, Ye K. N-Acetylserotonin: Circadian Activation of the BDNF Receptor and Neuroprotection in the Retina and Brain. Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology 801. 2014: 765–771. ISBN 978-1-4614-3208-1. PMC 4069859
. PMID 24664769. doi:10.1007/978-1-4614-3209-8_96.
- ^ Shen J, Ghai K, Sompol P, Liu X, Cao X, Iuvone PM, Ye K. N-acetyl serotonin derivatives as potent neuroprotectants for retinas. Proceedings of the National Academy of Sciences of the United States of America. February 2012, 109 (9): 3540–3545. Bibcode:2012PNAS..109.3540S. PMC 3295250
. PMID 22331903. doi:10.1073/pnas.1119201109
.