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HIOC

维基百科,自由的百科全书
HIOC
臨床資料
ATC碼
  • 未分配
识别信息
  • N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
CAS号314054-36-9
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C16H19N3O3
摩尔质量301.35 g·mol−1
3D模型(JSmol英语JSmol
  • c1cc2c(cc1O)c(c[nH]2)CCNC(=O)C3CCCNC3=O
  • InChI=1S/C16H19N3O3/c20-11-3-4-14-13(8-11)10(9-19-14)5-7-18-16(22)12-2-1-6-17-15(12)21/h3-4,8-9,12,19-20H,1-2,5-7H2,(H,17,21)(H,18,22)
  • Key:ZIMKJLALTRLXJO-UHFFFAOYSA-N

HIOC是一种含氮有机化合物,化学式C
16
H
19
N
3
O
3
,属于N-乙酰血清素(NAS)衍生物,可作为脑源性神经营养因子受体TrkB小分子激动剂[1][2][3]

参考文献

[编辑]
  1. ^ Longo FM, Massa SM. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nature Reviews. Drug Discovery. July 2013, 12 (7): 507–525. PMID 23977697. S2CID 33597483. doi:10.1038/nrd4024. 
  2. ^ Iuvone PM, Boatright JH, Tosini G, Ye K. N-Acetylserotonin: Circadian Activation of the BDNF Receptor and Neuroprotection in the Retina and Brain. Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology 801. 2014: 765–771. ISBN 978-1-4614-3208-1. PMC 4069859可免费查阅. PMID 24664769. doi:10.1007/978-1-4614-3209-8_96. 
  3. ^ Shen J, Ghai K, Sompol P, Liu X, Cao X, Iuvone PM, Ye K. N-acetyl serotonin derivatives as potent neuroprotectants for retinas. Proceedings of the National Academy of Sciences of the United States of America. February 2012, 109 (9): 3540–3545. Bibcode:2012PNAS..109.3540S. PMC 3295250可免费查阅. PMID 22331903. doi:10.1073/pnas.1119201109可免费查阅.