5-MeO-NiPT

5-MeO-NiPT
臨床資料
其他名稱	5-Methoxy-N-isopropyltryptamine
藥物類別	Serotonin receptor agonist; Serotonergic psychedelic; Hallucinogen
识别信息
	IUPAC命名法 N-[2-(5-methoxy-1H-indol-3-yl)ethyl]propan-2-amine; ;
CAS号	109921-55-3
PubChem CID	707167;
ChemSpider	616592;
UNII	CEP4J0P21U;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID00351701 ;
化学信息
化学式	C14H20N2O
摩尔质量	232.33 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES COc1ccc2c(c1)c(CCNC(C)C)c[nH]2;
	InChI InChI=1S/C14H20N2O/c1-10(2)15-7-6-11-9-16-14-5-4-12(17-3)8-13(11)14/h4-5,8-10,15-16H,6-7H2,1-3H3; Key:QQZJNZJNPDORBO-UHFFFAOYSA-N;

5-MeO-NiPT，化学名5-甲氧基-N-异丙基色胺（英語：5-methoxy-N-isopropyltryptamine）是一种含氮有机化合物，化学式C
14H
20N
2O，属于色胺衍生物^[1]^[2]^[3]，是5-MeO-MiPT（5-甲氧基-N-甲基-N-异丙基色胺）、5-MeO-DiPT（5-甲氧基-N,N-二异丙基色胺）在体内的活性代謝產物^[1]^[4]。

参考文献

^ ^1.0 ^1.1 Glatfelter GC, Clark AA, Cavalco NG, Landavazo A, Partilla JS, Naeem M, Golen JA, Chadeayne AR, Manke DR, Blough BE, McCorvy JD, Baumann MH. Serotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-N,N-dimethyltryptamine Analogs in Mice. ACS Chem Neurosci. December 2024, 15 (24): 4458–4477. PMID 39636099. doi:10.1021/acschemneuro.4c00513.
^ Puigseslloses P, Nadal-Gratacós N, Ketsela G, Weiss N, Berzosa X, Estrada-Tejedor R, Islam MN, Holy M, Niello M, Pubill D, Camarasa J, Escubedo E, Sitte HH, López-Arnau R. Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties. Mol Psychiatry. August 2024, 29 (8): 2346–2358. PMC 11412900 . PMID 38486047. doi:10.1038/s41380-024-02506-8.
^ Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB. Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology (Berl). October 2014, 231 (21): 4135–4144. PMC 4194234 . PMID 24800892. doi:10.1007/s00213-014-3557-7.
^ Araújo AM, Carvalho F, Bastos ML, Guedes de Pinho P, Carvalho M. The hallucinogenic world of tryptamines: an updated review (PDF). Archives of Toxicology. 2015, 89 (8): 1151–1173. Bibcode:2015ArTox..89.1151A. ISSN 0340-5761. PMID 25877327. doi:10.1007/s00204-015-1513-x.

[GlatfelterClarkCavalco2024-1] 1.0 ^1.1 Glatfelter GC, Clark AA, Cavalco NG, Landavazo A, Partilla JS, Naeem M, Golen JA, Chadeayne AR, Manke DR, Blough BE, McCorvy JD, Baumann MH. Serotonin 1A Receptors Modulate Serotonin 2A Receptor-Mediated Behavioral Effects of 5-Methoxy-N,N-dimethyltryptamine Analogs in Mice. ACS Chem Neurosci. December 2024, 15 (24): 4458–4477. PMID 39636099. doi:10.1021/acschemneuro.4c00513.

[PuigsesllosesNadal-GratacósKetsela2024-2] Puigseslloses P, Nadal-Gratacós N, Ketsela G, Weiss N, Berzosa X, Estrada-Tejedor R, Islam MN, Holy M, Niello M, Pubill D, Camarasa J, Escubedo E, Sitte HH, López-Arnau R. Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties. Mol Psychiatry. August 2024, 29 (8): 2346–2358. PMC 11412900 . PMID 38486047. doi:10.1038/s41380-024-02506-8.

[BloughLandavazoDecker2014-3] Blough BE, Landavazo A, Decker AM, Partilla JS, Baumann MH, Rothman RB. Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology (Berl). October 2014, 231 (21): 4135–4144. PMC 4194234 . PMID 24800892. doi:10.1007/s00213-014-3557-7.

[AraújoCarvalhoBastos2015-4] Araújo AM, Carvalho F, Bastos ML, Guedes de Pinho P, Carvalho M. The hallucinogenic world of tryptamines: an updated review (PDF). Archives of Toxicology. 2015, 89 (8): 1151–1173. Bibcode:2015ArTox..89.1151A. ISSN 0340-5761. PMID 25877327. doi:10.1007/s00204-015-1513-x.

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