GTS-21

GTS-21
临床资料
其他名称	3-(2,4-dimethoxy-benzylidene)anabaseine
识别信息
	IUPAC命名法 (3E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine; ;
CAS号	148372-04-7
PubChem CID	5310985;
ChemSpider	4470526;
UNII	8S399XDN2K;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID701027513 ;
化学信息
化学式	C19H20N2O2
摩尔质量	308.38 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES COc2cc(OC)ccc2C=C1CCCN=C1c3cnccc3;
	InChI InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+; Key:RPYWXZCFYPVCNQ-RVDMUPIBSA-N;

GTS-21（或称为3-(2,4-二甲氧基苯甲烯基)假木贼因，英语：3-(2,4-dimethoxy-benzylidene)anabaseine，缩写DMXBA）是一种含氮有机化合物，分子式C
19H
20N
2O
2，为新烟裂碱（假木贼因）衍生物，可用作烟碱型乙酰胆碱受体的部分激动剂^[1]^[2]。

参考文献

^ Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, Campbell JE, Decker MW, Donnelly-Roberts D, Elliott RL, Gopalakrishnan M, Holladay MW, Hui YH, Jackson WJ, Kim DJ, Marsh KC, O'Neill A, Prendergast MA, Ryther KB, Sullivan JP, Arneric SP. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacology, Biochemistry, and Behavior. 1997, 57 (1–2): 231–241. PMID 9164577. S2CID 205923953. doi:10.1016/S0091-3057(96)00354-1.
^ Meyer EM, Tay ET, Papke RL, Meyers C, Huang GL, de Fiebre CM. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Research. September 1997, 768 (1–2): 49–56. PMID 9369300. S2CID 13104716. doi:10.1016/S0006-8993(97)00536-2.