TRAF6

TRAF6
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1LB4、1LB5、1LB6、2ECI、2JMD、3HCS、3HCT、3HCU、4Z8M
識別號
别名	TRAF6；, MGC:3310, RNF85, TNF receptor associated factor 6
外部ID	OMIM：602355 MGI：108072 HomoloGene：3395 GeneCards：TRAF6
基因位置（人类）
染色体	11號染色體
终止	36,510,272 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	101,532,014 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• protein N-terminus binding; • histone deacetylase binding; • ubiquitin protein ligase activity; • 金屬離子結合; • mitogen-activated protein kinase kinase kinase binding; • 鋅離子結合; • 血浆蛋白结合; • thioesterase binding; • ubiquitin conjugating enzyme binding; • protein kinase binding; • protein kinase B binding; • 泛素蛋白轉移酶活性; • 相同蛋白质结合; • 泛素蛋白连接酶结合; • 轉移酶活性; • tumor necrosis factor receptor binding;
細胞組分	• 細胞質; • 细胞质基质; • 脂滴; • 细胞质的核周区域; • cytoplasmic side of plasma membrane; • 细胞核; • 细胞膜; • 细胞皮层; • endosome membrane; • CD40 receptor complex; • 大分子复合体;
生物學過程	• positive regulation of transcription regulatory region DNA binding; • response to interleukin-1; • toll-like receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • odontogenesis of dentin-containing tooth; • animal organ morphogenesis; • T-helper 1 type immune response; • toll-like receptor 9 signaling pathway; • regulation of apoptotic process; • 成骨作用; • cytokine-mediated signaling pathway; • osteoclast differentiation; • positive regulation of osteoclast differentiation; • stimulatory C-type lectin receptor signaling pathway; • activation of NF-kappaB-inducing kinase activity; • 骨质吸收; • JNK cascade; • membrane protein intracellular domain proteolysis; • protein ubiquitination; • positive regulation of T cell proliferation; • I-kappaB kinase/NF-kappaB signaling; • protein autoubiquitination; • immune system process; • positive regulation of JUN kinase activity; • positive regulation of DNA-binding transcription factor activity; • protein polyubiquitination; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • positive regulation of lipopolysaccharide-mediated signaling pathway; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of interleukin-2 production; • positive regulation of T cell cytokine production; • 免疫反应; • negative regulation of transcription, DNA-templated; • 含有信号通路的核苷酸结合寡聚结构域; • positive regulation of protein ubiquitination; • positive regulation of smooth muscle cell proliferation; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • cell development; • protein K63-linked ubiquitination; • myeloid dendritic cell differentiation; • MyD88-dependent toll-like receptor signaling pathway; • neural tube closure; • 骨的再建; • positive regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • cellular response to lipopolysaccharide; • T cell receptor signaling pathway; • activation of protein kinase activity; • positive regulation of transcription by RNA polymerase II; • 訊息傳遞; • cellular response to DNA damage stimulus; • protein deubiquitination; • regulation of I-kappaB kinase/NF-kappaB signaling; • interleukin-1-mediated signaling pathway; • cellular response to cytokine stimulus; • positive regulation of NIK/NF-kappaB signaling; • positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
直系同源
	7189
	22034
	ENSG00000175104
	ENSMUSG00000027164
	Q9Y4K3
	P70196
	NM_145803; NM_004620
	NM_009424; NM_001303273
	NP_004611; NP_665802
	NP_001290202; NP_033450
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF6是人类基因 TRAF6 编码的蛋白质，属于一种TNF受体相关因子（TRAF）。

蛋白质的相互作用

TRAF6蛋白与下列蛋白質进行互作：

ASK1^[5]^[6]^[7]
CD40^[8]^[9]
FHL2^[10]
HSPB2^[11]
IKBKG^[12]^[13]
IRAK1^[14]^[15]^[16]^[17]^[18]^[19]^[20]^[21]^[22]
IRAK2^[15]^[16]
TAB1^[23]^[24]^[25]
MAP3K7IP2^[12]^[22]^[23]^[24]^[26]^[27]
MAP3K7^[7]^[22]^[23]^[24]^[25]^[26]^[28]
PPP4C^[29]
RANK^[30]^[31]^[32]^[33]^[34]
SDCBP^[14]
SIGIRR^[35]
Sequestosome 1^[36]
TAX1BP1^[21]
TNFAIP3^[37]^[38]
TNFRSF13B^[39]
UBE2N^[40]
Ubiquitin C^[13]^[27]^[29]^[41]^[42]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000175104 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027164 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell. September 1998, 2 (3): 389–95. PMID 9774977. doi:10.1016/s1097-2765(00)80283-x .
^ Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. October 1999, 18 (42): 5814–20. PMID 10523862. S2CID 12132452. doi:10.1038/sj.onc.1202975.
^ ^7.0 ^7.1 Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H. ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction. J. Biol. Chem. October 2000, 275 (42): 32747–52. PMID 10921914. doi:10.1074/jbc.M003042200 .
^ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc. Natl. Acad. Sci. U.S.A. February 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .
^ Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
^ Bai S, Zha J, Zhao H, Ross FP, Teitelbaum SL. Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts. J. Biol. Chem. November 2008, 283 (45): 30861–7. PMC 2662164 . PMID 18768464. doi:10.1074/jbc.M802525200 .
^ Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z. HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cell. Signal. January 2009, 21 (1): 143–50. PMID 18950704. doi:10.1016/j.cellsig.2008.10.001.
^ ^12.0 ^12.1 Windheim M, Stafford M, Peggie M, Cohen P. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol. Cell. Biol. March 2008, 28 (5): 1783–91. PMC 2258775 . PMID 18180283. doi:10.1128/MCB.02380-06.
^ ^13.0 ^13.1 Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J. Biol. Chem. September 2008, 283 (36): 24871–80. PMC 2529010 . PMID 18617513. doi:10.1074/jbc.M802749200 .
^ ^14.0 ^14.1 Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D. Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling. Cell. Signal. April 2008, 20 (4): 666–74. PMID 18234474. S2CID 28812149. doi:10.1016/j.cellsig.2007.12.002.
^ ^15.0 ^15.1 Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. July 1999, 274 (27): 19403–10. PMID 10383454. doi:10.1074/jbc.274.27.19403 .
^ ^16.0 ^16.1 Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. November 1997, 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. PMID 9374458. doi:10.1126/science.278.5343.1612.
^ Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J. Biol. Chem. November 2001, 276 (45): 41661–7. PMID 11518704. doi:10.1074/jbc.M102262200 .
^ Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature. October 1996, 383 (6599): 443–6. Bibcode:1996Natur.383..443C. PMID 8837778. S2CID 4269027. doi:10.1038/383443a0.
^ Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J. Biol. Chem. April 2003, 278 (14): 12144–50. PMID 12566447. doi:10.1074/jbc.M300720200 .
^ Li S, Strelow A, Fontana EJ, Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. U.S.A. April 2002, 99 (8): 5567–72. Bibcode:2002PNAS...99.5567L. PMC 122810 . PMID 11960013. doi:10.1073/pnas.082100399 .
^ ^21.0 ^21.1 Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc. Natl. Acad. Sci. U.S.A. August 2000, 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. PMC 16905 . PMID 10920205. doi:10.1073/pnas.170279097 .
^ ^22.0 ^22.1 ^22.2 Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. Biol. April 2001, 21 (7): 2475–84. PMC 86880 . PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001.
^ ^23.0 ^23.1 ^23.2 Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell. April 2000, 5 (4): 649–58. PMID 10882101. doi:10.1016/s1097-2765(00)80244-0 .
^ ^24.0 ^24.1 ^24.2 Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y. Unutmaz D , 编. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLOS ONE. 2008, 3 (12): e4064. Bibcode:2008PLoSO...3.4064W. PMC 2603309 . PMID 19112497. doi:10.1371/journal.pone.0004064 .
^ ^25.0 ^25.1 Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature. March 1999, 398 (6724): 252–6. Bibcode:1999Natur.398..252N. PMID 10094049. S2CID 4421236. doi:10.1038/18465.
^ ^26.0 ^26.1 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. Dec 2003, 22 (23): 6277–88. PMC 291846 . PMID 14633987. doi:10.1093/emboj/cdg605.
^ ^27.0 ^27.1 Ma Q, Zhou L, Shi H, Huo K. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cell. Signal. June 2008, 20 (6): 1044–51. PMID 18299187. doi:10.1016/j.cellsig.2008.01.015.
^ Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landström M. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat. Cell Biol. October 2008, 10 (10): 1199–207. PMID 18758450. S2CID 22984417. doi:10.1038/ncb1780.
^ ^29.0 ^29.1 Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y. Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6. FEBS Lett. August 2008, 582 (19): 2843–9. Bibcode:2008FEBSL.582.2843C. PMID 18634786. S2CID 27700566. doi:10.1016/j.febslet.2008.07.014 .
^ Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. February 2002, 22 (4): 992–1000. PMC 134634 . PMID 11809792. doi:10.1128/mcb.22.4.992-1000.2002.
^ Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J. Biol. Chem. August 1998, 273 (32): 20551–5. PMID 9685412. doi:10.1074/jbc.273.32.20551 .
^ Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J. Biol. Chem. March 1999, 274 (12): 7724–31. PMID 10075662. doi:10.1074/jbc.274.12.7724 .
^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J. Biol. Chem. Dec 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .
^ Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH. Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. FEBS Lett. January 1999, 443 (3): 297–302. Bibcode:1999FEBSL.443..297K. PMID 10025951. S2CID 46210019. doi:10.1016/s0014-5793(98)01731-1 .
^ Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat. Immunol. September 2003, 4 (9): 920–7. PMID 12925853. S2CID 25246605. doi:10.1038/ni968.
^ Sanz L, Diaz-Meco MT, Nakano H, Moscat J. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. April 2000, 19 (7): 1576–86. PMC 310227 . PMID 10747026. doi:10.1093/emboj/19.7.1576.
^ Heyninck K, Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. January 1999, 442 (2–3): 147–50. Bibcode:1999FEBSL.442..147H. PMID 9928991. S2CID 19072203. doi:10.1016/s0014-5793(98)01645-7 .
^ Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ. Isolation and characterization of two novel A20-like proteins. Biochem. J. August 2001, 357 (Pt 3): 617–23. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.
^ Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J. Exp. Med. July 2000, 192 (1): 137–43. PMC 1887716 . PMID 10880535. doi:10.1084/jem.192.1.137.
^ Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. October 2000, 103 (2): 351–61. PMID 11057907. S2CID 18154645. doi:10.1016/s0092-8674(00)00126-4 .
^ Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell. August 2008, 134 (4): 668–78. PMID 18724939. S2CID 3955385. doi:10.1016/j.cell.2008.07.039 .
^ Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol. Cell. Biol. May 2008, 28 (10): 3538–47. PMC 2423148 . PMID 18347055. doi:10.1128/MCB.02098-07.

外部链接

醫學主題詞表（MeSH）：TRAF6

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000175104 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027164 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774977-5] Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell. September 1998, 2 (3): 389–95. PMID 9774977. doi:10.1016/s1097-2765(00)80283-x .

[pmid10523862-6] Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. October 1999, 18 (42): 5814–20. PMID 10523862. S2CID 12132452. doi:10.1038/sj.onc.1202975.

[pmid10921914-7] 7.0 ^7.1 Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H. ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction. J. Biol. Chem. October 2000, 275 (42): 32747–52. PMID 10921914. doi:10.1074/jbc.M003042200 .

[pmid9990007-8] Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc. Natl. Acad. Sci. U.S.A. February 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .

[pmid9384571-9] Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.

[pmid18768464-10] Bai S, Zha J, Zhao H, Ross FP, Teitelbaum SL. Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts. J. Biol. Chem. November 2008, 283 (45): 30861–7. PMC 2662164 . PMID 18768464. doi:10.1074/jbc.M802525200 .

[pmid18950704-11] Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z. HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cell. Signal. January 2009, 21 (1): 143–50. PMID 18950704. doi:10.1016/j.cellsig.2008.10.001.

[pmid18180283-12] 12.0 ^12.1 Windheim M, Stafford M, Peggie M, Cohen P. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol. Cell. Biol. March 2008, 28 (5): 1783–91. PMC 2258775 . PMID 18180283. doi:10.1128/MCB.02380-06.

[pmid18617513-13] 13.0 ^13.1 Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J. Biol. Chem. September 2008, 283 (36): 24871–80. PMC 2529010 . PMID 18617513. doi:10.1074/jbc.M802749200 .

[pmid18234474-14] 14.0 ^14.1 Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D. Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling. Cell. Signal. April 2008, 20 (4): 666–74. PMID 18234474. S2CID 28812149. doi:10.1016/j.cellsig.2007.12.002.

[pmid10383454-15] 15.0 ^15.1 Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. July 1999, 274 (27): 19403–10. PMID 10383454. doi:10.1074/jbc.274.27.19403 .

[pmid9374458-16] 16.0 ^16.1 Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. November 1997, 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. PMID 9374458. doi:10.1126/science.278.5343.1612.

[pmid11518704-17] Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J. Biol. Chem. November 2001, 276 (45): 41661–7. PMID 11518704. doi:10.1074/jbc.M102262200 .

[pmid8837778-18] Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature. October 1996, 383 (6599): 443–6. Bibcode:1996Natur.383..443C. PMID 8837778. S2CID 4269027. doi:10.1038/383443a0.

[pmid12566447-19] Takatsuna H, Kato H, Gohda J, Akiyama T, Moriya A, Okamoto Y, Yamagata Y, Otsuka M, Umezawa K, Semba K, Inoue J. Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J. Biol. Chem. April 2003, 278 (14): 12144–50. PMID 12566447. doi:10.1074/jbc.M300720200 .

[pmid11960013-20] Li S, Strelow A, Fontana EJ, Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. U.S.A. April 2002, 99 (8): 5567–72. Bibcode:2002PNAS...99.5567L. PMC 122810 . PMID 11960013. doi:10.1073/pnas.082100399 .

[pmid10920205-21] 21.0 ^21.1 Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc. Natl. Acad. Sci. U.S.A. August 2000, 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. PMC 16905 . PMID 10920205. doi:10.1073/pnas.170279097 .

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