TAX1BP1

TAX1BP1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2M7Q、4BMJ、4NLH、5AAS、4Z4M、4Z4K
識別號
别名	TAX1BP1；, CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
外部ID	OMIM：605326 MGI：1289308 HomoloGene：4395 GeneCards：TAX1BP1
基因位置（人类）
染色体	7號染色體
终止	27,844,564 bp
基因位置（小鼠）
染色体	小鼠6号染色体
终止	52,743,765 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本體
分子功能	• 激酶结合; • 血浆蛋白结合; • 金屬離子結合;
細胞組分	• 细胞质基质; • 外排體;
生物學過程	• 肿瘤坏死因子介导的信号通路的调控; • negative regulation of type I interferon production; • negative regulation of apoptotic process; • negative regulation of NF-kappaB transcription factor activity; • 细胞凋亡;
	Sources:Amigo / QuickGO
直系同源
	8887
	52440
	ENSG00000106052
	ENSMUSG00000004535
	Q86VP1
	Q3UKC1
NM_001079864; NM_001206901; NM_001206902; NM_006024; NM_001362794;
	NM_001362795
	NM_025816; NM_001355595; NM_001355596
NP_001073333; NP_001193830; NP_001193831; NP_006015; NP_001349723;
	NP_001349724
	NP_080092; NP_001342524; NP_001342525
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TAX1BP1（Tax1 binding protein 1，“Tax1结合蛋白1”）也称为CALCOCO3（Calcium-binding and coiled-coil domain-containing protein 3，“钙结合和卷曲螺旋区蛋白3”）是人类基因 TAX1BP1 编码的蛋白质^[5]，其名称来源于能和人類嗜T淋巴球病毒一型（HTLV-1）的蛋白Tax1结合^[5]。

蛋白质的相互作用

TAX1BP1蛋白与下列蛋白質进行互作：A20^[6]和TRAF6^[7]，在与A20或TRAF6结合后抑制NF-κB转录因子激活。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1.
^ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. July 1999, 18 (29): 4182–90. PMID 10435631. doi:10.1038/sj.onc.1202787 .
^ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proceedings of the National Academy of Sciences of the United States of America. August 2000, 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. PMC 16905 . PMID 10920205. doi:10.1073/pnas.170279097 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 5.0 ^5.1 Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1.

[pmid10435631-6] De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. July 1999, 18 (29): 4182–90. PMID 10435631. doi:10.1038/sj.onc.1202787 .

[pmid10920205-7] Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proceedings of the National Academy of Sciences of the United States of America. August 2000, 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. PMC 16905 . PMID 10920205. doi:10.1073/pnas.170279097 .

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