CALCOCO2

CALCOCO2
已知的結構
PDB	人类UniProt搜索: PDBe RCSB
PDBID列表
	3VVV、3VVW、4GXL、4HAN、2MXP、4XKL
識別號
别名	CALCOCO2；, NDP52, calcium binding and coiled-coil domain 2
外部ID	OMIM：604587 HomoloGene：31339 GeneCards：CALCOCO2
基因位置（人类）
染色体	17號染色體
终止	48,866,522 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • protein homodimerization activity;
細胞組分	• 細胞質; • 细胞质的核周区域; • 自噬体; • autophagosome membrane; • 细胞骨架; • 膜; • cytoplasmic vesicle; • 细胞核; • 細胞內膜結合細胞器; • 细胞质基质;
生物學過程	• 自噬; • viral process; • positive regulation of autophagosome maturation; • response to interferon-gamma; • 異種吞噬;
	Sources:Amigo / QuickGO
直系同源
	10241
	无数据
	ENSG00000136436
	无数据
	Q13137
	无数据
	NM_001261390; NM_001261391; NM_001261393; NM_001261395; NM_005831
	无数据
	NP_001248319; NP_001248320; NP_001248322; NP_001248324; NP_005822
	无数据
	維基數據
檢視/編輯人類

CALCOCO2（Calcium-binding and coiled-coil domain-containing protein 2，“钙结合和卷曲螺旋区蛋白2”，也称为NDP52，nuclear domain protein 52）是人类基因 CALCOCO2 编码的蛋白质^[3]^[4]，为一种自噬受体^[5]。

另见

CALCOCO1
TAX1BP1（CALCOCO3）

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136436 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Korioth F, Gieffers C, Maul GG, Frey J. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. The Journal of Cell Biology. July 1995, 130 (1): 1–13. PMC 2120522 . PMID 7540613. doi:10.1083/jcb.130.1.1.
^ Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2.
^ Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nature Genetics. December 2022, 55 (1): 54–65. PMC 9839450 . PMID 36543916. doi:10.1038/s41588-022-01261-2 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000136436 - Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7540613-3] Korioth F, Gieffers C, Maul GG, Frey J. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. The Journal of Cell Biology. July 1995, 130 (1): 1–13. PMC 2120522 . PMID 7540613. doi:10.1083/jcb.130.1.1.

[entrez-4] Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2.

[5] Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nature Genetics. December 2022, 55 (1): 54–65. PMC 9839450 . PMID 36543916. doi:10.1038/s41588-022-01261-2 .

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