SCH-51866
（重定向自C19H18F3N5O）
| SCH-51866 | |
|---|---|
| |
| IUPAC名 (6aR,9aS)-5-Methyl-2-[4-(trifluoromethyl)benzyl]-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(3H)-one | |
| 识别 | |
| CAS号 | 167298-74-0 
|
| PubChem | 15473392 |
| ChemSpider | 26377910 |
| SMILES |
|
| InChI |
|
| InChIKey | JOSMPBVYYKRYLG-OLZOCXBDSA-N |
| IUPHAR配体 | 5270 |
| 性质 | |
| 化学式 | C19H18F3N5O |
| 摩尔质量 | 389.37 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
SCH-51866是一种含氮有机氟化合物，分子式C
19H
18F
3N
5O，可作为第一型和第五型磷酸二酯酶抑制劑（PDE1、PDE5抑制剂）[1][2]。
参考文献
[编辑]- ^ Lusche, DF; Kaneko, H; Malchow, D. cGMP-Phosphodiesterase Antagonists Inhibit Ca2+-Influx in Dictyostelium discoideum and Bovine Cyclic-Nucleotide-Gated-Channel. European Journal of Pharmacology. 18 April 2005, 513 (1–2): 9–20. PMID 15878705. doi:10.1016/j.ejphar.2005.01.047.
- ^ Beaumont, V; Park, L; Rassoulpour, A; Dijkman, U; Heikkinen, T; Lehtimaki, K; Kontkanen, O; Al Nackkash, R; Bates, GP; Gleyzes, M; Steidl, E; Ramboz, S; Murphy, C; Beconi, MG; Dominguez, C; Munoz-Sanjuan, I. The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease. PLOS Currents. 13 February 2014, 6. PMC 3923778
. PMID 24558637. doi:10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca .
