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帕金森综合症

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维基百科,自由的百科全书
帕金森综合症
Parkinsonism
病因
分类和外部资源
医学专科神经学
ICD-118A00
ICD-10G21、​G22
DiseasesDB24212
MedlinePlus000759
Orphanet68402
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帕金森综合症(Parkinsonism)是和运动机能相关的临床综合症,其特征是颤抖运动功能减退僵硬英语Rigidity (neurology)平衡障碍[1][2]。在帕金森氏症(PD)患者身上会有类似症状(此综合症因此而得名),而路易氏体痴呆症(DLB)、帕金森病性痴呆症英语Parkinson's disease dementia(PDD)等疾病也会有此症状。这类综合症的病因范围很广,包括神经退化障碍疾病、药物、毒素代谢疾病,或是帕金森氏症以外的神经性疾病[3]

病因

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药物引起

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有帕金森综合症的人当中,约有7%是因为药物的副作用而造成的,主要是因为抗精神病药,特别是吩噻嗪(例如perphenazine及氯丙嗪)、噻吨英语thioxanthene(例如三氟噻吨英语flupenthixol珠氯噻醇英语zuclopenthixol)及丁酰苯(例如氟哌啶醇),偶尔也有因为抗忧郁药物而造成。药物引起帕金森综合症的盛行率会随年龄而上升。药物引起的帕金森综合症一但出现,多半会维持原有的程度,不像帕金森氏症会渐渐恶化[4]

毒素

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有发现杀虫剂或除草剂暴露程度和帕金森氏症之间的关联性。若暴露在百草枯锰乃浦英语Maneb/锌锰乃浦英语Mancozeb下,风险是原来的两倍[5]

已证实慢性(Mn)暴露会造成类似帕金森综合症的疾病,其特征是运动障碍,此症状无法用典型的帕金森症治疗方式英语Management of Parkinson's disease来治疗,因此推测除了典型黑质多巴胺能损失外,包括有其他的致病途径[6]。锰会在基底核内累积,因此造成运动障碍[7]有一种和SLC30A10基因(锰外流转运蛋白,减少细胞内锰所必需的蛋白)有关的变异和这种类似帕金森综合症疾病有关[8]。在这疾病中看不到帕金森氏症中典型的路易体英语Lewy body[7]

诊断

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许多疾病会造成帕金森综合症。

神经退化障碍帕金森附加综合症英语Parkinson plus syndrome[9]
药物引发(伪帕金森综合症)
感染
毒素
创伤
血管的
其他

原发性震颤

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根据2018年的回顾性研究,还不确定帕金森综合症和原发性震颤英语essential tremor是否有关[30]

参考资料

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  1. ^ 1.0 1.1 Aminoff MJ, Greenberg DA, Simon RP. Chapter 7: Movement disorders. Clinical Neurology 6th. Lange: McGraw-Hill Medical. 2005: 241–45. ISBN 978-0-07-142360-1. 
  2. ^ Tobottom BJ, Weiner WJ, Shulman LM. Chapter 42: Parkinsonism. Lisak RP, Truong DD, Carroll W, Bhidayasiri R (编). International Neurology: A Clinical Approach. Blackwell Publishing Ltd. 2009-09-28: 152–58. ISBN 978-1-405-15738-4. 
  3. ^ Christine, Chadwick W.; Aminoff, Michael J. Clinical differentiation of parkinsonian syndromes: Prognostic and therapeutic relevance. The American Journal of Medicine. 2004-09-15, 117 (6). ISSN 0002-9343. doi:10.1016/j.amjmed.2004.03.032 (英语). 
  4. ^ Information Sheet: Drug-induced Parkinsonism (PDF). Parkinson’s Disease and Society. [2013-04-15]. (原始内容 (PDF)存档于2013-06-26). 
  5. ^ 5.0 5.1 5.2 Pezzoli, Gianni; Cereda, Emanuele. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology. 2013-05-28, 80 (22) [2022-10-15]. ISSN 0028-3878. PMID 23713084. doi:10.1212/WNL.0b013e318294b3c8. (原始内容存档于2023-03-03) (英语). 
  6. ^ 6.0 6.1 Guilarte, Tomás R.; Gonzales, Kalynda K. Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson’s Disease: Environmental and Genetic Evidence. Toxicological Sciences. 2015-08, 146 (2) [2022-10-15]. ISSN 1096-6080. PMC 4607750可免费查阅. PMID 26220508. doi:10.1093/toxsci/kfv099. (原始内容存档于2022-12-19) (英语). 
  7. ^ 7.0 7.1 Kwakye, Gunnar; Paoliello, Monica; Mukhopadhyay, Somshuvra; Bowman, Aaron; Aschner, Michael. Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features. International Journal of Environmental Research and Public Health. 2015-07-06, 12 (7) [2022-10-15]. ISSN 1660-4601. PMC 4515672可免费查阅. PMID 26154659. doi:10.3390/ijerph120707519. (原始内容存档于2023-01-30) (英语). 
  8. ^ Peres, Tanara V.; Schettinger, Maria Rosa C.; Chen, Pan; Carvalho, Fabiano; Avila, Daiana S.; Bowman, Aaron B.; Aschner, Michael. “Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”. BMC Pharmacology and Toxicology. 2016-12, 17 (1) [2022-10-15]. ISSN 2050-6511. PMC 5097420可免费查阅. PMID 27814772. doi:10.1186/s40360-016-0099-0. (原始内容存档于2023-02-02) (英语). 
  9. ^ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 9.18 9.19 9.20 9.21 9.22 9.23 9.24 9.25 9.26 9.27 9.28 9.29 9.30 9.31 9.32 Jankovic J, Lang AE. Diagnosis and Assessment. Bradley, Walter George (编). Neurology in Clinical Practice: Principles of diagnosis and management. Volume 1. Taylor & Francis. 2004: 295–96. ISBN 9789997625885. 
  10. ^ Finger EC. Frontotemporal Dementias. Continuum (Review). April 2016, 22 (2 Dementia): 464–89. PMC 5390934可免费查阅. PMID 27042904. doi:10.1212/CON.0000000000000300. 
  11. ^ McKeith, Ian G.; Boeve, Bradley F.; Dickson, Dennis W.; Halliday, Glenda; Taylor, John-Paul; Weintraub, Daniel; Aarsland, Dag; Galvin, James; Attems, Johannes; Ballard, Clive G.; Bayston, Ashley. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017-07-04, 89 (1). ISSN 0028-3878. PMC 5496518可免费查阅. PMID 28592453. doi:10.1212/WNL.0000000000004058 (英语). 
  12. ^ Louis, E. D.; Ottman, R. Is there a one-way street from essential tremor to Parkinson's disease? Possible biological ramifications. European Journal of Neurology. 2013-11, 20 (11) [2022-10-15]. ISSN 1468-1331. PMC 3801177可免费查阅. PMID 24033795. doi:10.1111/ene.12256. (原始内容存档于2022-10-20). 
  13. ^ Fabrizi, Monaco, Dalla Libera. Parkinsonian syndrome following MDMA (Ecstasy) addiction. Movement Disorders. 2004, 19: S73–S74. 
  14. ^ Maltête, David; Guyant-Maréchal, Lucie; Mihout, Bruno; Hannequin, Didier. Movement disorders and Creutzfeldt-Jakob disease: A review. Parkinsonism & Related Disorders. 2006-03-01, 12 (2). ISSN 1353-8020. PMID 16364674. doi:10.1016/j.parkreldis.2005.10.004 (英语). 
  15. ^ Tse W, Cersosimo MG, Gracies JM, Morgello S, Olanow CW, Koller W. Movement disorders and AIDS: a review. Parkinsonism & Related Disorders. August 2004, 10 (6): 323–34. PMID 15261874. doi:10.1016/j.parkreldis.2004.03.001. 
  16. ^ Carod-Artal, F. J. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Revista De Neurologia. 2003-05, 36 (9) [2022-10-15]. ISSN 0210-0010. PMID 12717675. (原始内容存档于2022-10-16). 
  17. ^ Kim EA, Kang SK. Occupational neurological disorders in Korea. Journal of Korean Medical Science (Review). December 2010, 25 (Suppl): S26–35. PMC 3023358可免费查阅. PMID 21258587. doi:10.3346/jkms.2010.25.S.S26. 
  18. ^ Watanabe Y, Himeda T, Araki T. Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease (PDF). Medical Science Monitor. January 2005, 11 (1): RA17–23 [2019-12-08]. PMID 15614202. (原始内容存档 (PDF)于2016-03-04). 
  19. ^ 19.0 19.1 Nandipati S, Litvan I. Environmental Exposures and Parkinson's Disease. International Journal of Environmental Research and Public Health (Review). September 2016, 13 (9): 881. PMC 5036714可免费查阅. PMID 27598189. doi:10.3390/ijerph13090881. 
  20. ^ Weiss, Janet. Chapter 151. Toluene and Xylene. Olson, Kent R. (编). Poisoning & Drug Overdose 6. New York, NY: The McGraw-Hill Companies. 2012. 
  21. ^ Uitti RJ, Snow BJ, Shinotoh H, Vingerhoets FJ, Hayward M, Hashimoto S, Richmond J, Markey SP, Markey CJ, Calne DB. Parkinsonism induced by solvent abuse. Annals of Neurology. May 1994, 35 (5): 616–9. PMID 8179306. doi:10.1002/ana.410350516. 
  22. ^ Jubault T, Brambati SM, Degroot C, Kullmann B, Strafella AP, Lafontaine AL, Chouinard S, Monchi O. Gendelman HE , 编. Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI. PLOS ONE. December 2009, 4 (12): e8247. Bibcode:2009PLoSO...4.8247J. PMC 2784293可免费查阅. PMID 20011063. doi:10.1371/journal.pone.0008247. 
  23. ^ Port, Dr Beckie. What brain areas are affected by Parkinson's?. Medium. 2018-06-04 [2019-03-28]. (原始内容存档于2021-07-21). 
  24. ^ Kuoppamäki M, Rothwell JC, Brown RG, Quinn N, Bhatia KP, Jahanshahi M. Parkinsonism following bilateral lesions of the globus pallidus: performance on a variety of motor tasks shows similarities with Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. April 2005, 76 (4): 482–90. PMC 1739601可免费查阅. PMID 15774432. doi:10.1136/jnnp.2003.020800. 
  25. ^ Halliday, Glenda M. Thalamic changes in Parkinson's disease. Parkinsonism & Related Disorders. 2009-12-15, 15: S152–S155. PMID 20082979. doi:10.1016/S1353-8020(09)70804-1 (英语). 
  26. ^ Apartis E, Tison F, Arné P, Jedynak CP, Vidailhet M. Fast orthostatic tremor in Parkinson's disease mimicking primary orthostatic tremor. Movement Disorders. November 2001, 16 (6): 1133–6. PMID 11748748. doi:10.1002/mds.1218. 
  27. ^ Panzer J, Dalmau J. Movement disorders in paraneoplastic and autoimmune disease. Current Opinion in Neurology. August 2011, 24 (4): 346–53. PMC 3705177可免费查阅. PMID 21577108. doi:10.1097/WCO.0b013e328347b307. 
  28. ^ Liu Y, Lu Y, Zhang X, Xie S, Wang T, Wu T, Wang C. A case of rapid-onset dystonia-parkinsonism accompanied by pyramidal tract impairment. BMC Neurology. November 2016, 16 (1): 218. PMC 5105251可免费查阅. PMID 27835968. doi:10.1186/s12883-016-0743-8. 
  29. ^ Saito M, Maruyama M, Ikeuchi K, Kondo H, Ishikawa A, Yuasa T, Tsuji S. Autosomal recessive juvenile parkinsonism. Brain & Development. September 2000,. 22 Suppl 1: S115–7. PMID 10984671. 
  30. ^ Algarni M, Fasano A. The overlap between Essential tremor and Parkinson disease. Parkinsonism & Related Disorders. January 2018,. 46 Suppl 1: S101–S104. PMID 28729090. doi:10.1016/j.parkreldis.2017.07.006. 

外部链接

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