植物乳杆菌PS128

植物乳杆菌PS128是植物乳杆菌的一个特殊品种，是乳杆菌属的细菌。在植物基质、肉类、牛奶以及人类的胃肠道中都能找到此类细菌。

前临床研究

植物乳杆菌 PS128 在多项动物实验中展现潜在的神经心理健康相关作用，涵盖阿兹海默症、自闭症、焦虑及压力调节等方面。

一项发表于《BMC Complementary Medicine & Therapies》的研究中，研究者使用脑部注射 streptozotocin 建立阿兹海默症样认知障碍小鼠模型，发现口服 PS128 可改善学习与记忆能力。该研究指出，PS128 能抑制 GSK3β 活性、降低 tau 蛋白磷酸化与 Aβ 沉积，减少神经胶质增生，并提升突触蛋白 PSD95 水准。^[1]

在另一项发表于《Frontiers in Nutrition》的研究中，研究人员使用丙戊酸诱导自闭症光谱障碍（ASD）小鼠模型，发现 PS128 可改善其社交行为与空间记忆表现，并提升催产素及其受体表现。同时也观察到肠道菌相改变（如双歧杆菌属增加）与行为改善呈正相关。^[2]

临床研究

PS128 近年来被应用于多项神经心理健康相关的前瞻性临床研究中。

2021 年，美国麻省总医院（Massachusetts General Hospital）进行一项开放标签的前瞻性试验，针对 8–21 岁自闭症族群受试者补充 PS128，为期八周。结果显示受试者在情绪反应、注意力与日常功能指标方面皆有改善，且家长报告情绪调节与整体行为有所改善。^[3]

PS128 亦于 2022 年被纳入意大利进行的肌少症与情绪调节研究中，显示对老年人群情绪困扰有部分改善效果。^[4]

产品

参见

参考文献

^ Yang, Ying-Chieh; Chou, Chih-Yin; Chen, Hsin-Yi; Chien, Yen-Ho; Lin, Chuan-Mu; Huang, Chi-Chang. Oral administration of Lactobacillus plantarum PS128 prevents cognitive dysfunction in streptozotocin-induced mouse model of Alzheimer’s disease. BMC Complementary Medicine and Therapies. 2022, 22 (1): 256. PMID 34627204. doi:10.1186/s12906-022-03700-1.
^ Lin, Wei-Hsiang; Tsai, Ying-Chieh; Chen, Jyun-Yi; Yang, Yu-Tang; Wang, Su-Ching. Psychobiotic Lactiplantibacillus plantarum PS128 improves social deficits and gut–brain axis in valproate-induced rodent model of autism. Frontiers in Nutrition. 2023, 10: 1215292. PMID 38841895. doi:10.3389/fnut.2023.1215292.
^ Arnold, Lauren E.; Butter, E.; Guy, W.; Pan, Chang H.; Howard, J.; Weiss, M. D. Open-Label Study of a Probiotic Supplement Containing Lactobacillus plantarum PS128 in Children With Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology. 2021, 31 (9): 636–641. PMID 34713241. doi:10.1089/cap.2021.0041.
^ Scarpellini, Elisabetta; Rinninella, Erika; Gagliardi, Andrea; Alleruzzo, Laura; Gasbarrini, Antonio; Mele, Maria C. Probiotics in the Management of Sarcopenia: A Randomized Controlled Trial. Nutrients. 2022, 14 (21): 4566. PMID 36363094. doi:10.3390/nu14214566.

[1] Yang, Ying-Chieh; Chou, Chih-Yin; Chen, Hsin-Yi; Chien, Yen-Ho; Lin, Chuan-Mu; Huang, Chi-Chang. Oral administration of Lactobacillus plantarum PS128 prevents cognitive dysfunction in streptozotocin-induced mouse model of Alzheimer’s disease. BMC Complementary Medicine and Therapies. 2022, 22 (1): 256. PMID 34627204. doi:10.1186/s12906-022-03700-1.

[2] Lin, Wei-Hsiang; Tsai, Ying-Chieh; Chen, Jyun-Yi; Yang, Yu-Tang; Wang, Su-Ching. Psychobiotic Lactiplantibacillus plantarum PS128 improves social deficits and gut–brain axis in valproate-induced rodent model of autism. Frontiers in Nutrition. 2023, 10: 1215292. PMID 38841895. doi:10.3389/fnut.2023.1215292.

[3] Arnold, Lauren E.; Butter, E.; Guy, W.; Pan, Chang H.; Howard, J.; Weiss, M. D. Open-Label Study of a Probiotic Supplement Containing Lactobacillus plantarum PS128 in Children With Autism Spectrum Disorder. Journal of Child and Adolescent Psychopharmacology. 2021, 31 (9): 636–641. PMID 34713241. doi:10.1089/cap.2021.0041.

[4] Scarpellini, Elisabetta; Rinninella, Erika; Gagliardi, Andrea; Alleruzzo, Laura; Gasbarrini, Antonio; Mele, Maria C. Probiotics in the Management of Sarcopenia: A Randomized Controlled Trial. Nutrients. 2022, 14 (21): 4566. PMID 36363094. doi:10.3390/nu14214566.

[1]

[2]

[3]

[4]