AC-42
| AC-42 | |
|---|---|
| |
| IUPAC名 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine | |
| 识别 | |
| CAS号 | 244291-63-2  [ChemSpider]
|
| PubChem | 9948320 |
| ChemSpider | 8123931 |
| SMILES |
|
| IUPHAR配体 | 289 |
| 性质 | |
| 化学式 | C20H31NO |
| 摩尔质量 | 301.47 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
AC-42是一种含氮有机化合物，分子式C
20H
31NO，可作为蕈毒碱型乙酰胆碱受体M1的选择性别构激动剂[1][2][3]。
参考文献
[编辑]- ^ Decker, Michael; Holzgrabe, Ulrike. M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease. MedChemComm. 2012, 3 (7): 752. doi:10.1039/c2md20025b.
- ^ Sams, Anette G.; Hentzer, Morten; Mikkelsen, Gitte K.; Larsen, Krestian; Bundgaard, Christoffer; Plath, Niels; Christoffersen, Claus T.; Bang-Andersen, Benny. Discovery of N 1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential. Journal of Medicinal Chemistry. 9 September 2010, 53 (17): 6386–6397. PMID 20684563. doi:10.1021/jm100697g.
- ^ Daval, Sandrine B.; Valant, Céline; Bonnet, Dominique; Kellenberger, Esther; Hibert, Marcel; Galzi, Jean-Luc; Ilien, Brigitte. Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors (PDF). Journal of Medicinal Chemistry. 8 March 2012, 55 (5): 2125–2143. PMID 22329602. doi:10.1021/jm201348t.