普利多匹定
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| 临床资料 | |
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| ATC码 |
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| 识别信息 | |
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| CAS号 | 346688-38-8 |
| PubChem CID | |
| DrugBank | |
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| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.240.998 |
| 化学信息 | |
| 化学式 | C15H23NO2S |
| 摩尔质量 | 281.41 g·mol−1 |
| 3D模型（JSmol） | |
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普利多匹定（英语：Pridopidine，开发代号：PL-101）是一种含氮有机硫化合物，化学式C
15H
23NO
2S，带有苯基砜基团，可作为σ1受体的选择性激动剂[1][2][3] 。
参考文献
[编辑]- ^ Ionescu A, Gradus T, Altman T, Maimon R, Saraf Avraham N, Geva M, Hayden M, Perlson E. Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model. Cell Death & Disease. March 2019, 10 (3): 210. PMC 6397200
. PMID 30824685. doi:10.1038/s41419-019-1451-2.
- ^ Geva M, Gershoni-Emek N, Naia L, Ly P, Mota S, Rego AC, Hayden MR, Levin LA. Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma. Scientific Reports. November 2021, 11 (1): 21975. Bibcode:2021NatSR..1121975G. PMC 8578336 . PMID 34753986. doi:10.1038/s41598-021-01077-w.
- ^ Francardo V, Geva M, Bez F, Denis Q, Steiner L, Hayden MR, Cenci MA. Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease. Neurotherapeutics. April 2019, 16 (2): 465–479. PMC 6554374 . PMID 30756361. doi:10.1007/s13311-018-00699-9.
