VAC14

VAC14
識別號
别名	VAC14；, ArPIKfyve, TAX1BP2, TRX, Vac14, PIKFYVE complex component, VAC14 component of PIKFYVE complex
外部ID	OMIM：604632 MGI：2157980 HomoloGene：6528 GeneCards：VAC14
相關疾病
	striatonigral degeneration, childhood-onset; SNDC
基因位置（人类）
染色体	16號染色體
终止	70,801,160 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	111,447,030 bp
基因本體
分子功能	• 血浆蛋白结合; • signaling receptor activity;
細胞組分	• organelle membrane; • Golgi membrane; • 核内体; • early endosome membrane; • endosome membrane; • PAS complex; • 内质网; • late endosome membrane; • 膜; • 細胞內膜結合細胞器; • extrinsic component of vacuolar membrane;
生物學過程	• viral process; • 訊息傳遞; • phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	55697
	234729
	ENSG00000103043
	ENSMUSG00000010936
	Q08AM6
	Q80WQ2
	NM_018052; NM_001351157
	NM_146216
	NP_060522; NP_001338086
	NP_666328
	維基數據
檢視/編輯人類	檢視/編輯小鼠

VAC14也称为ArPIKfyve（Associated Regulator of PIKfyve，“PIKfyve相关调节因子”）或TAX1BP2（Tax1 binding protein 2，“Tax1结合蛋白2”）是人类基因 VAC14 编码的蛋白质^[6]^[7]^[8]。

参考文献

^ 與VAC14相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103043 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000010936 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: Vac14 homolog (S. cerevisiae).
^ Davy BE, Robinson ML. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Human Molecular Genetics. May 2003, 12 (10): 1163–1170. PMID 12719380. doi:10.1093/hmg/ddg122 .
^ Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Molecular and Cellular Biology. December 2004, 24 (23): 10437–10447. PMC 529046 . PMID 15542851. doi:10.1128/MCB.24.23.10437-10447.2004.

[1] 與VAC14相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000103043 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000010936 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-6] Entrez Gene: Vac14 homolog (S. cerevisiae).

[pmid12719380-7] Davy BE, Robinson ML. Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. Human Molecular Genetics. May 2003, 12 (10): 1163–1170. PMID 12719380. doi:10.1093/hmg/ddg122 .

[pmid15542851-8] Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, et al. A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Molecular and Cellular Biology. December 2004, 24 (23): 10437–10447. PMC 529046 . PMID 15542851. doi:10.1128/MCB.24.23.10437-10447.2004.

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