U-48800

U-48800
识别信息
	IUPAC命名法 2-(2,4-dichlorophenyl)-N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-N-methylacetamide; ;
CAS号	2370977-17-4
PubChem CID	137700072;
UNII	C1X8MF00M5;
化学信息
化学式	C17H24Cl2N2O
摩尔质量	343.29 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CN(C)[C@H]1CCCC[C@@H]1N(C)C(=O)CC2=C(C=C(C=C2)Cl)Cl;
	InChI InChI=1S/C17H24Cl2N2O/c1-20(2)15-6-4-5-7-16(15)21(3)17(22)10-12-8-9-13(18)11-14(12)19/h8-9,11,15-16H,4-7,10H2,1-3H3/t15-,16-/m0/s1; Key:FKUWIGXXBMULOI-HOTGVXAUSA-N;

U-48800是一种含氮有机氯化合物，化学式C
17H
24Cl
2N
2O，可作为類阿片镇痛药，由Upjohn公司研发^[1]^[2]^[3]^[4]^[5] 。

参考文献

^ Gampfer TM, Richter LH, Schäper J, Wagmann L, Meyer MR. Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding. Drug Testing and Analysis. October 2019, 11 (10): 1572–1580. PMID 31424163. doi:10.1002/dta.2683.
^ Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ. U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market. Brain Sciences. November 2020, 10 (11): 895. PMC 7700279 . PMID 33238449. doi:10.3390/brainsci10110895 .
^ Fogarty MF, Mohr AL, Papsun DM, Logan BK. Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800. Journal of Analytical Toxicology. February 2022, 46 (1): 17–24. PMID 33237987. doi:10.1093/jat/bkaa180.
^ Otte L, Wilde M, Auwärter V, Grafinger KE. Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [³⁵ S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800. Drug Testing and Analysis. July 2022, 14 (7): 1187–1199. PMID 35142070. doi:10.1002/dta.3238 .
^ Amend N, Thiermann H, Worek F, Wille T. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists. Toxicology Letters. June 2023, 382: 41–46. PMID 37245850. doi:10.1016/j.toxlet.2023.05.010 .

[pmid31424163-1] Gampfer TM, Richter LH, Schäper J, Wagmann L, Meyer MR. Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding. Drug Testing and Analysis. October 2019, 11 (10): 1572–1580. PMID 31424163. doi:10.1002/dta.2683.

[pmid33238449-2] Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ. U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market. Brain Sciences. November 2020, 10 (11): 895. PMC 7700279 . PMID 33238449. doi:10.3390/brainsci10110895 .

[3] Fogarty MF, Mohr AL, Papsun DM, Logan BK. Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800. Journal of Analytical Toxicology. February 2022, 46 (1): 17–24. PMID 33237987. doi:10.1093/jat/bkaa180.

[4] Otte L, Wilde M, Auwärter V, Grafinger KE. Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [³⁵ S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800. Drug Testing and Analysis. July 2022, 14 (7): 1187–1199. PMID 35142070. doi:10.1002/dta.3238 .

[5] Amend N, Thiermann H, Worek F, Wille T. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists. Toxicology Letters. June 2023, 382: 41–46. PMID 37245850. doi:10.1016/j.toxlet.2023.05.010 .

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