促甲状腺激素β亚基

促甲状腺激素β亚基
識別號
别名	TSHB；, TSH-B, TSH-BETA, thyroid stimulating hormone beta, Thyroid stimulating hormone, beta, thyroid stimulating hormone subunit beta
外部ID	OMIM：188540 MGI：98848 HomoloGene：463 GeneCards：TSHB
基因位置（人类）
染色体	1號染色體
终止	115,034,302 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	102,690,034 bp
基因本體
分子功能	• hormone activity;
細胞組分	• 細胞外區域; • 細胞外空間; • 細胞質;
生物學過程	• response to calcium ion; • cell-cell signaling; • anatomical structure morphogenesis; • G protein-coupled receptor signaling pathway; • response to vitamin A; • peptide hormone processing; • response to estrogen; • hormone-mediated signaling pathway; • regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
直系同源
	7252
	22094
	ENSG00000134200
	ENSMUSG00000027857
	P01222
	P12656,E9Q4F3
	NM_000549; NM_001277991
	NM_001165939; NM_001165940; NM_009432
	NP_000540; NP_001264920
	NP_001159411; NP_001159412; NP_033458
	維基數據
檢視/編輯人類	檢視/編輯小鼠

促甲状腺激素β亚基（英語：Thyroid stimulating hormone, beta，简称TSHB）是一个由人类基因TSHB 编码的蛋白质^[5]^[6]。化学式为C₆₂₈H₉₅₃O₂₀₁N₁₅₃S₁₄^[7]

功能

促甲状腺激素（TSH）是由两个亚基非共价连接而成的糖蛋白，其α亚基为该类激素所共有，而β亚基则是独有的^[8]。

另见

促甲状腺激素

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000134200 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027857 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem. September 1988, 263 (25): 12538–42 [2014-03-29]. PMID 2457586. （原始内容存档于2020-04-25）.
^ Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.
^ UniProt. UniProt. [2025-06-01] （英语）.
^ Entrez Gene: TSHB. （原始内容存档于2010-04-12）.

延伸阅读

Bonomi M, Proverbio MC, Weber G; et al. Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.. J. Clin. Endocrinol. Metab. 2001, 86 (4): 1600–4. PMID 11297590. doi:10.1210/jc.86.4.1600.
Vuissoz JM, DeladoÃ«y J, Buyukgebiz A; et al. New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.. J. Clin. Endocrinol. Metab. 2001, 86 (9): 4468–71. PMID 11549695. doi:10.1210/jc.86.9.4468.
Karges B, LeHeup B, Schoenle E; et al. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.. Horm. Res. 2004, 62 (3): 149–55. PMID 15297803. doi:10.1159/000080071.
Kabadi UM, Premachandra BN. Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?. Endocr Pract. 2007, 13 (6): 615–9. PMID 17954417.
Miyai S, Yoshimura S, Iwasaki Y; et al. Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.. Cell Tissue Res. 2005, 322 (2): 269–77. PMID 16133148. doi:10.1007/s00441-005-0033-z.
Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1971, 89 (6): 1331–44. PMID 5002675. doi:10.1210/endo-89-6-1331.
Atzmon G, Barzilai N, Surks MI, Gabriely I. Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity. J. Clin. Endocrinol. Metab. 2009, 94 (12): 4768–75. PMC 2795660 . PMID 19837933. doi:10.1210/jc.2009-0808.
Landa I, Ruiz-Llorente S, Montero-Conde C; et al. Gibson, Greg , 编. The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors. PLoS Genet. 2009, 5 (9): e1000637. PMC 2727793 . PMID 19730683. doi:10.1371/journal.pgen.1000637.
Pohlenz J, Dumitrescu A, Aumann U; et al. Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene. J. Clin. Endocrinol. Metab. 2002, 87 (1): 336–9. PMID 11788671. doi:10.1210/jc.87.1.336.
Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994, 52 (4): 940–7. PMID 8196184.
Borck G, Topaloglu AK, Korsch E; et al. Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect. J. Clin. Endocrinol. Metab. 2004, 89 (8): 4136–41. PMID 15292359. doi:10.1210/jc.2004-0494.
Comings DE, Gade-Andavolu R, Gonzalez N; et al. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clin. Genet. 2000, 58 (5): 375–85. PMID 11140838. doi:10.1034/j.1399-0004.2000.580508.x.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Clark AG, Glanowski S, Nielsen R; et al. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science. 2003, 302 (5652): 1960–3. PMID 14671302. doi:10.1126/science.1088821.
Loinder K, Söderström M. An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene. J. Steroid Biochem. Mol. Biol. 2005, 97 (4): 322–7. PMID 16216492. doi:10.1016/j.jsbmb.2005.06.031.
Luttrell LM. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Mol. Biotechnol. 2008, 39 (3): 239–64. PMID 18240029. doi:10.1007/s12033-008-9031-1.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Brumm H, Pfeufer A, Biebermann H; et al. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. J. Clin. Endocrinol. Metab. 2002, 87 (10): 4811–6. PMID 12364478. doi:10.1210/jc.2002-020297.
Benhadi N, Wiersinga WM, Reitsma JB; et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur. J. Endocrinol. 2009, 160 (6): 985–91. PMID 19273570. doi:10.1530/EJE-08-0953.
Schaefer JS, Klein JR. A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid. Gen. Comp. Endocrinol. 2009, 162 (3): 241–4. PMC 2689139 . PMID 19364510. doi:10.1016/j.ygcen.2009.04.006.

促甲状腺激素β亚基引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000134200 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027857 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2457586-5] Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem. September 1988, 263 (25): 12538–42 [2014-03-29]. PMID 2457586. （原始内容存档于2020-04-25）.

[pmid3243440-6] Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.

[7] UniProt. UniProt. [2025-06-01] （英语）.

[entrez-8] Entrez Gene: TSHB. （原始内容存档于2010-04-12）.

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