TRAF7

TRAF7
識別號
别名	TRAF7；, RFWD1, RNF119, TNF receptor associated factor 7, CAFDADD
外部ID	OMIM：606692 MGI：3042141 HomoloGene：12998 GeneCards：TRAF7
基因位置（人类）
染色体	16號染色體
终止	2,178,129 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	24,746,912 bp
基因本體
分子功能	• 鋅離子結合; • 血浆蛋白结合; • 金屬離子結合; • 轉移酶活性; • 泛素蛋白轉移酶活性;
細胞組分	• ubiquitin ligase complex; • 细胞膜; • 細胞內膜結合細胞器; • cytoplasmic vesicle; • 核仁;
生物學過程	• 细胞凋亡; • positive regulation of apoptotic signaling pathway; • regulation of transcription, DNA-templated; • protein ubiquitination; • transcription, DNA-templated; • positive regulation of MAPK cascade; • ribosomal large subunit assembly; • Notch信号通路; • regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
直系同源
	84231
	224619
	ENSG00000131653
	ENSMUSG00000052752
	Q6Q0C0
	Q922B6
	NM_032271; NM_206835
	NM_001172113; NM_001172114; NM_153792
	NP_115647
	无数据
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF7（“TNF受体相关因子7”，TNF receptor associated factor 7，也称为“环指和WD重复结构域1”，ring finger and WD repeat domain 1，缩写“RFWD3”）是人类基因 TRAF7 编码的蛋白质，属于一种TNF受体相关因子（TRAF）^[5]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

外部链接

醫學主題詞表（MeSH）：TRAF7

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000131653 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000052752 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid21518757-5] Zotti, T; Uva, A; Ferravante, A; Vessichelli, M; Scudiero, I; Ceccarelli, M; Vito, P; Stilo, R. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation.. The Journal of biological chemistry. 2011-07-01, 286 (26): 22924–33. PMID 21518757. doi:10.1074/jbc.M110.215426.

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