TRAF5

TRAF5
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4GJH
識別號
别名	TRAF5；, MGC:39780, RNF84, TNF receptor associated factor 5
外部ID	OMIM：602356 MGI：107548 HomoloGene：27079 GeneCards：TRAF5
基因位置（人类）
染色体	1號染色體
终止	211,374,946 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	191,776,868 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• thioesterase binding; • 鋅離子結合; • 血浆蛋白结合; • 泛素蛋白连接酶结合; • 金屬離子結合; • 相同蛋白质结合; • tumor necrosis factor receptor binding;
細胞組分	• 细胞质基质; • cytoplasmic side of plasma membrane; • 中心体; • CD40 receptor complex; • 細胞質; • 大分子复合体;
生物學過程	• regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • positive regulation of DNA-binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity; • 訊息傳遞; • 细胞凋亡;
	Sources:Amigo / QuickGO
直系同源
	7188
	22033
	ENSG00000082512
	ENSMUSG00000026637
	O00463
	P70191
	NM_001033910; NM_004619; NM_145759; NM_001319207
	NM_011633
	NP_001029082; NP_001306136; NP_004610; NP_665702
	NP_035763
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF5（“TNF受体相关因子5”，TNF receptor associated factor 5，也称为“环指因子84”，RING finger protein 84，缩写“RNF84”）是人类基因 TRAF5 编码的蛋白质，属于一种TNF受体相关因子（TRAF）。

蛋白质的相互作用

TRAF5蛋白与下列蛋白質进行互作：

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000082512 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026637 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Molecular Cell. Sep 1998, 2 (3): 389–95. PMID 9774977. doi:10.1016/s1097-2765(00)80283-x .
^ Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. Oct 1999, 18 (42): 5814–20. PMID 10523862. S2CID 12132452. doi:10.1038/sj.onc.1202975.
^ Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. The Journal of Biological Chemistry. Mar 1998, 273 (10): 5808–14. PMID 9488716. doi:10.1074/jbc.273.10.5808 .
^ Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. The Journal of Biological Chemistry. Jan 1997, 272 (4): 2042–5. PMID 8999898. doi:10.1074/jbc.272.4.2042 .
^ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proceedings of the National Academy of Sciences of the United States of America. Feb 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .
^ Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proceedings of the National Academy of Sciences of the United States of America. Sep 1996, 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. PMC 38446 . PMID 8790348. doi:10.1073/pnas.93.18.9437 .
^ Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. The Journal of Biological Chemistry. Aug 1998, 273 (32): 20551–5. PMID 9685412. doi:10.1074/jbc.273.32.20551 .
^ Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. The Journal of Biological Chemistry. Mar 1999, 274 (12): 7724–31. PMID 10075662. doi:10.1074/jbc.274.12.7724 .
^ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. The Journal of Biological Chemistry. Dec 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .
^ Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. The Journal of Experimental Medicine. Jul 2000, 192 (1): 137–43. PMC 1887716 . PMID 10880535. doi:10.1084/jem.192.1.137.
^ Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. The Journal of Biological Chemistry. May 1997, 272 (21): 13471–4. PMID 9153189. doi:10.1074/jbc.272.21.13471 .
^ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. The Journal of Biological Chemistry. May 1997, 272 (22): 14029–32. PMID 9162022. doi:10.1074/jbc.272.22.14029 .

外部链接

醫學主題詞表（MeSH）：TRAF5

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000082512 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000026637 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774977-5] Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Molecular Cell. Sep 1998, 2 (3): 389–95. PMID 9774977. doi:10.1016/s1097-2765(00)80283-x .

[pmid10523862-6] Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. Oct 1999, 18 (42): 5814–20. PMID 10523862. S2CID 12132452. doi:10.1038/sj.onc.1202975.

[pmid9488716-7] Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. The Journal of Biological Chemistry. Mar 1998, 273 (10): 5808–14. PMID 9488716. doi:10.1074/jbc.273.10.5808 .

[pmid8999898-8] Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. The Journal of Biological Chemistry. Jan 1997, 272 (4): 2042–5. PMID 8999898. doi:10.1074/jbc.272.4.2042 .

[pmid9990007-9] Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proceedings of the National Academy of Sciences of the United States of America. Feb 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446 . PMID 9990007. doi:10.1073/pnas.96.4.1234 .

[pmid8790348-10] Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proceedings of the National Academy of Sciences of the United States of America. Sep 1996, 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. PMC 38446 . PMID 8790348. doi:10.1073/pnas.93.18.9437 .

[pmid9685412-11] Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB. Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. The Journal of Biological Chemistry. Aug 1998, 273 (32): 20551–5. PMID 9685412. doi:10.1074/jbc.273.32.20551 .

[pmid10075662-12] Darnay BG, Ni J, Moore PA, Aggarwal BB. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. The Journal of Biological Chemistry. Mar 1999, 274 (12): 7724–31. PMID 10075662. doi:10.1074/jbc.274.12.7724 .

[pmid9852070-13] Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC. The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. The Journal of Biological Chemistry. Dec 1998, 273 (51): 34120–7. PMID 9852070. doi:10.1074/jbc.273.51.34120 .

[pmid10880535-14] Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. The Journal of Experimental Medicine. Jul 2000, 192 (1): 137–43. PMC 1887716 . PMID 10880535. doi:10.1084/jem.192.1.137.

[pmid9153189-15] Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. The Journal of Biological Chemistry. May 1997, 272 (21): 13471–4. PMID 9153189. doi:10.1074/jbc.272.21.13471 .

[pmid9162022-16] Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. The Journal of Biological Chemistry. May 1997, 272 (22): 14029–32. PMID 9162022. doi:10.1074/jbc.272.22.14029 .

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