TRAF4

TRAF4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2EOD、2YUC、3ZJB、4K8U、4M4E
識別號
别名	TRAF4；, CART1, MLN62, RNF83, TNF receptor associated factor 4
外部ID	OMIM：602464 MGI：1202880 HomoloGene：3173 GeneCards：TRAF4
基因位置（人类）
染色体	17號染色體
终止	28,750,956 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	78,056,415 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • 鋅離子結合; • 金屬離子結合; • 血浆蛋白结合; • WW domain binding; • thioesterase binding; • tumor necrosis factor receptor binding; • protein kinase binding; • 泛素蛋白连接酶结合; • 相同蛋白质结合;
細胞組分	• 細胞質; • 膜; • 双细胞紧密连接; • 细胞膜; • 细胞连接; • 细胞质的核周区域; • 细胞骨架; • 细胞核; • 大分子复合体; • 胞內;
生物學過程	• regulation of apoptotic process; • activation of NF-kappaB-inducing kinase activity; • positive regulation of JNK cascade; • positive regulation of protein homodimerization activity; • respiratory gaseous exchange by respiratory system; • multicellular organism development; • respiratory tube development; • 訊息傳遞; • positive regulation of protein kinase activity; • 细胞凋亡;
	Sources:Amigo / QuickGO
直系同源
	9618
	22032
	ENSG00000076604
	ENSMUSG00000017386
	Q9BUZ4
	Q61382
	NM_004295; NM_145751
	NM_009423
	NP_004286
	NP_033449
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TRAF4（“TNF受体相关因子4”，TNF receptor associated factor 4，也称为“环指因子83”，RING finger protein 83，缩写“RNF83”）是人类基因 TRAF4 编码的蛋白质，属于一种TNF受体相关因子（TRAF）。

蛋白质的相互作用

TRAF4蛋白与下列蛋白質进行互作：

神经生长因子受体 p75（NTR/NTSR1）^[5]^[6]

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000076604 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017386 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J. Biol. Chem. October 1999, 274 (42): 30202–8. PMID 10514511. doi:10.1074/jbc.274.42.30202 .
^ Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am. J. Pathol. June 1998, 152 (6): 1549–61. PMC 1858434 . PMID 9626059.

外部链接

醫學主題詞表（MeSH）：TRAF4

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000076604 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000017386 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10514511-5] Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. J. Biol. Chem. October 1999, 274 (42): 30202–8. PMID 10514511. doi:10.1074/jbc.274.42.30202 .

[pmid9626059-6] Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. Am. J. Pathol. June 1998, 152 (6): 1549–61. PMC 1858434 . PMID 9626059.

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