TIGIT

TIGIT
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	3Q0H、3RQ3、3UCR、3UDW
識別號
别名	TIGIT；, VSIG9, VSTM3, WUCAM, T-cell immunoreceptor with Ig and ITIM domains, T cell immunoreceptor with Ig and ITIM domains
外部ID	OMIM：612859 MGI：3642260 HomoloGene：18358 GeneCards：TIGIT
基因位置（人类）
染色体	3號染色體
终止	114,310,288 bp
基因位置（小鼠）
染色体	小鼠16号染色体
终止	43,484,509 bp
基因本體
分子功能	• signaling receptor binding; • 血浆蛋白结合; • protein homodimerization activity; • cell adhesion molecule binding; • 相同蛋白质结合;
細胞組分	• integral component of membrane; • cell surface; • 细胞膜; • integral component of plasma membrane; • 膜;
生物學過程	• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • cell recognition; • negative regulation of T cell activation; • positive regulation of interleukin-10 production; • homophilic cell adhesion via plasma membrane adhesion molecules; • negative regulation of interleukin-12 production;
	Sources:Amigo / QuickGO
直系同源
	201633
	100043314
	ENSG00000181847
	ENSMUSG00000071552
	Q495A1
	P86176,A0A0B4J1G6
	NM_173799
	NM_001146325
	NP_776160
	NP_001139797
	維基數據
檢視/編輯人類	檢視/編輯小鼠

TIGIT^[5](又叫含IgG和ITIM结构域T细胞免疫受体)。是存在于一些T细胞和自然杀伤细胞(NK)的免疫受体。^[6]它又被称作是WUCAM^[7]和Vstm3^[8]。TIGIT可以高亲和力结合樹突狀細胞(DCs)和巨噬细胞等上的CD155(PVR)，低亲和力结合CD112 (PVRL2)。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000181847 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000071552 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lung Cancer and Immunotherapy with Dr. Patrick Forde and Oswald Peterson. YouTube. October 22, 2021 [5 July 2022].
^ Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. Jan 2009, 10 (1): 48–57. PMID 19011627. S2CID 205361984. doi:10.1038/ni.1674.
^ Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. European Journal of Immunology. Mar 2009, 39 (3): 695–703. PMC 3544471 . PMID 19197944. doi:10.1002/eji.200839116.
^ Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, et al. Vstm3 is a member of the CD28 family and an important modulator of T-cell function. European Journal of Immunology. April 2011, 41 (4): 902–15. PMC 3733993 . PMID 21416464. doi:10.1002/eji.201041136.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000181847 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000071552 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lung Cancer and Immunotherapy with Dr. Patrick Forde and Oswald Peterson. YouTube. October 22, 2021 [5 July 2022].

[surface_protein-6] Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. Jan 2009, 10 (1): 48–57. PMID 19011627. S2CID 205361984. doi:10.1038/ni.1674.

[7] Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. European Journal of Immunology. Mar 2009, 39 (3): 695–703. PMC 3544471 . PMID 19197944. doi:10.1002/eji.200839116.

[pmid21416464-8] Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, et al. Vstm3 is a member of the CD28 family and an important modulator of T-cell function. European Journal of Immunology. April 2011, 41 (4): 902–15. PMC 3733993 . PMID 21416464. doi:10.1002/eji.201041136.

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