SKF-77,434

SKF-77,434
识别信息
	IUPAC命名法 3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol; ;
CAS号	104422-04-0
PubChem CID	1241;
ChemSpider	1204 ;
UNII	XA99M7XZR5;
ChEBI	CHEBI:63988;
ChEMBL	ChEMBL288090;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID3043817 ;
化学信息
化学式	C19H21NO2
摩尔质量	295.38 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES c3ccccc3C2CN(CC=C)CCc(cc1O)c2cc1O;
	InChI InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2; Key:QBUVZVXIRYFENV-UHFFFAOYSA-N;

SKF-77,434是一种含氮有机化合物，化学式C
19H
21NO
2，属于多巴胺受体D₁的选择性部分激动剂，能作为兴奋剂。^[1]^[2]^[3]^[4]^[5]^[6]^[7]

参考文献

^ Grech DM, Spealman RD, Bergman J. Self-administration of D1 receptor agonists by squirrel monkeys. Psychopharmacology. May 1996, 125 (2): 97–104. PMID 8783382. S2CID 36378721. doi:10.1007/BF02249407.
^ Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL. The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 29–38. PMID 9336305.
^ Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. The Journal of Pharmacology and Experimental Therapeutics. June 2000, 293 (3): 1017–26. PMID 10869406.
^ Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology. September 2001, 157 (2): 208–16. PMID 11594448. S2CID 6567384. doi:10.1007/s002130100779.
^ Mutschler NH, Bergman J. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology. April 2002, 160 (4): 362–70. PMID 11919663. S2CID 20483120. doi:10.1007/s00213-001-0976-z.
^ Desai RI, Terry P, Katz JL. A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice. Pharmacology, Biochemistry, and Behavior. August 2005, 81 (4): 843–8. PMID 16000217. S2CID 2525256. doi:10.1016/j.pbb.2005.06.006.
^ Katz JL, Kopajtic TA, Terry P. Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats. Behavioural Pharmacology. June 2006, 17 (4): 303–9. PMID 16914948. S2CID 24288989. doi:10.1097/01.fbp.0000205015.67079.f7.

[1] Grech DM, Spealman RD, Bergman J. Self-administration of D1 receptor agonists by squirrel monkeys. Psychopharmacology. May 1996, 125 (2): 97–104. PMID 8783382. S2CID 36378721. doi:10.1007/BF02249407.

[2] Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL. The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 29–38. PMID 9336305.

[3] Platt DM, Rowlett JK, Spealman RD. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. The Journal of Pharmacology and Experimental Therapeutics. June 2000, 293 (3): 1017–26. PMID 10869406.

[4] Platt DM, Rowlett JK, Spealman RD. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology. September 2001, 157 (2): 208–16. PMID 11594448. S2CID 6567384. doi:10.1007/s002130100779.

[5] Mutschler NH, Bergman J. Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys. Psychopharmacology. April 2002, 160 (4): 362–70. PMID 11919663. S2CID 20483120. doi:10.1007/s00213-001-0976-z.

[6] Desai RI, Terry P, Katz JL. A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice. Pharmacology, Biochemistry, and Behavior. August 2005, 81 (4): 843–8. PMID 16000217. S2CID 2525256. doi:10.1016/j.pbb.2005.06.006.

[7] Katz JL, Kopajtic TA, Terry P. Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats. Behavioural Pharmacology. June 2006, 17 (4): 303–9. PMID 16914948. S2CID 24288989. doi:10.1097/01.fbp.0000205015.67079.f7.

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