SB-366791

SB-366791
识别信息
	IUPAC命名法 (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide; ;
CAS号	472981-92-3
PubChem CID	667594;
ChemSpider	580962;
UNII	E8EY4M2N4H;
ChEBI	CHEBI:93038;
ChEMBL	ChEMBL122413;
化学信息
化学式	C16H14ClNO2
摩尔质量	287.74 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl;
	InChI InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+; Key:RYAMDQKWNKKFHD-JXMROGBWSA-N;

SB-366791是一种含氮有机氯化合物，分子式C
16H
14ClNO
2，属于酰胺，能用作离子通道 TRPV1的选择性阻断剂^[1]^[2]^[3]。

参考文献

^ Dell H. New compound fires up pain research. Drug Discovery Today. December 2003, 8 (23): 1053. PMID 14693457. doi:10.1016/s1359-6446(03)02928-3.
^ Ma SX, Kim HC, Lee SY, Jang CG. TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens. Neurochemistry International. December 2018, 121: 1–7. PMID 30292787. S2CID 52929149. doi:10.1016/j.neuint.2018.10.009.
^ Uchytilova E, Spicarova D, Palecek J. Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist. International Journal of Molecular Sciences. April 2021, 22 (7): 3712. PMC 8038144 . PMID 33918267. doi:10.3390/ijms22073712 .