OSU-6162

OSU-6162
臨床資料
ATC碼	未分配;
识别信息
	IUPAC命名法 (3S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine; ;
CAS号	156907-84-5
PubChem CID	9795741;
ChemSpider	7971507;
UNII	V5SBJBUJW6;
ChEMBL	ChEMBL311730;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID40431531 ;
ECHA InfoCard	100.216.320
化学信息
化学式	C15H23NO2S
摩尔质量	281.41 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCN1CCC[C@H](C1)C2=CC(=CC=C2)S(=O)(=O)C;
	InChI InChI=1S/C15H23NO2S/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3/t14-/m1/s1; Key:GZVBVBMMNFIXGE-CQSZACIVSA-N;

OSU-6162，也称为PNU-96391，是一种含氮有机硫化合物，化学式C
15H
23NO
2S，结构上与普利多匹定（PL-101）类似，可作为多巴胺受體D₂和5-HT_2A受体的部分激动剂^[1]^[2]^[3]。

参考文献

^ Ekesbo A, Andrén PE, Gunne LM, Tedroff J. (-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease. NeuroReport. July 1997, 8 (11): 2567–70. PMID 9261828. S2CID 29806568. doi:10.1097/00001756-199707280-00029.
^ Tedroff J, Torstenson R, Hartvig P, Sonesson C, Waters N, Carlsson A, et al. Effects of the substituted (S)-3-phenylpiperidine (-)-OSU6162 on PET measurements in subhuman primates: evidence for tone-dependent normalization of striatal dopaminergic activity. Synapse. April 1998, 28 (4): 280–7. PMID 9517836. S2CID 2090820. doi:10.1002/(SICI)1098-2396(199804)28:4<280::AID-SYN3>3.0.CO;2-5.
^ Tedroff J, Ekesbo A, Sonesson C, Waters N, Carlsson A. Long-lasting improvement following (-)-OSU6162 in a patient with Huntington's disease. Neurology. October 1999, 53 (7): 1605–6. PMID 10534281. doi:10.1212/wnl.53.7.1605.