JWH-098

JWH-098
法律規範狀態
法律規範	加：Schedule II; 德：NpSG; 英：Class B; 美：附表I;
识别信息
	IUPAC命名法 4-Methoxynaphthalen-1-yl-(1-pentyl-2-methylindol-3-yl)methanone; ;
CAS号	316189-74-9
PubChem CID	45272116;
ChemSpider	24628229;
UNII	T27V33219F;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID80185501 ;
化学信息
化学式	C26H27NO2
摩尔质量	385.51 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCCCn(c1C)c2ccccc2c1C(=O)c(ccc3OC)c4ccccc34;
	InChI InChI=1S/C26H27NO2/c1-4-5-10-17-27-18(2)25(22-13-8-9-14-23(22)27)26(28)21-15-16-24(29-3)20-12-7-6-11-19(20)21/h6-9,11-16H,4-5,10,17H2,1-3H3; Key:CNTCHEBQQFICNR-UHFFFAOYSA-N;

JWH-098，化学名N-正戊基-2-甲基-3-(4-甲氧基-1-萘甲酰基)吲哚，分子式C
26H
27NO
2，属于萘甲酰基吲哚类JWH系列大麻素，是大麻素受体CB₁和CB₂的激动剂^[2]。

在氯化铝存在下，它可以被氢化铝锂还原为JWH-197^[3]。

参考文献

^ Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 (2023-07-25) [2023-08-27]. （原始内容存档于2023-08-27）（巴西葡萄牙语）.
^ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorganic & Medicinal Chemistry. January 2005, 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.
^ Huffman, John W; Mabon, Ross; Wu, Ming-Jung; Lu, Jianzhong; Hart, Richard; Hurst, Dow P; Reggio, Patricia H; Wiley, Jenny L; Martin, Billy R. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorganic & Medicinal Chemistry. 2003-02, 11 (4): 539–549. doi:10.1016/s0968-0896(02)00451-0.