H-151

H-151
识别信息
	IUPAC命名法 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea; ;
CAS号	941987-60-6
PubChem CID	7616033;
化学信息
化学式	C17H17N3O
摩尔质量	279.34 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32;
	InChI InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21); Key:UJZDIKVQFMCLBE-UHFFFAOYSA-N;

H-151是一种含氮有机化合物，分子式C
17H
17N
3O，可作为干扰素基因刺激蛋白（STING）的不可逆抑制剂。^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10]^[11]

参考文献

^ Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R, Ablasser A. Targeting STING with covalent small-molecule inhibitors. Nature. July 2018, 559 (7713): 269–273. Bibcode:2018Natur.559..269H. PMID 29973723. doi:10.1038/s41586-018-0287-8.
^ Liu Y, Lu X, Qin N, Qiao Y, Xing S, Liu W, Feng F, Liu Z, Sun H. STING, a promising target for small molecular immune modulator: A review. European Journal of Medicinal Chemistry. February 2021, 211: 113113. PMID 33360799. doi:10.1016/j.ejmech.2020.113113.
^ Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Nature. March 2022, 603 (7899): 145–151. Bibcode:2022Natur.603..145D. PMC 8891013 . PMID 35045565. doi:10.1038/s41586-022-04421-w.
^ Kobritz M, Borjas T, Patel V, Coppa G, Aziz M, Wang P. H151, A Small Molecule Inhibitor of Sting as a Novel Therapeutic in Intestinal Ischemia-Reperfusion Injury. Shock. September 2022, 58 (3): 241–250. PMC 9489661 . PMID 35959789. doi:10.1097/SHK.0000000000001968.
^ Zhao J, Xiao R, Zeng R, He E, Zhang A. Small molecules targeting cGAS-STING pathway for autoimmune disease. European Journal of Medicinal Chemistry. August 2022, 238: 114480. PMID 35635952. doi:10.1016/j.ejmech.2022.114480.
^ Wu G, Zhang Y, Niu L, Hu Y, Yang Y, Zhao Y. Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway. Virus Research. May 2024, 343: 199344. PMC 10982080 . PMID 38431054. doi:10.1016/j.virusres.2024.199344.
^ Tanaka M, Yasuda H, Nakamura S, Shimazawa M. H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. July 2024, 65 (8): 16. PMC 11235146 . PMID 38980271. doi:10.1167/iovs.65.8.16.
^ Ge X, Liu Q, Fan H, Yu H, Li J, Li Y, Qin B, Ma J, Wang J, Hu Y. STING facilitates the development of radiation-induced lung injury via regulating the PERK/eIF2α pathway. Translational Lung Cancer Research. November 2024, 13 (11): 3010–3025. PMC 11632424 . PMID 39670000. doi:10.21037/tlcr-24-649 .
^ Xia L, Jiang JH, Liu JY, Zhang TY, Dong YX, Liu QH, Chai YF, Liu YC, Shou ST. H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway. Renal Failure. December 2024, 46 (2): 2363591. PMC 11168233 . PMID 38856314. doi:10.1080/0886022X.2024.2363591.
^ Liu Z, Qin Q, Wang S, Kang X, Liu Y, Wei L, Lu Z, Cai W, Hu M. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS Neuroscience & Therapeutics. December 2024, 30 (12): e70106. PMC 11656094 . PMID 39698742. doi:10.1111/cns.70106.
^ Sun Y, Zou S, Xu X, Xu S, Sun H, Tang M, Kong W, Chen X, He Z. Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage. Neuroscience Bulletin. March 2025, 41 (3): 359–373. PMC 11876498 . PMID 39676140. doi:10.1007/s12264-024-01334-8.

[1] Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R, Ablasser A. Targeting STING with covalent small-molecule inhibitors. Nature. July 2018, 559 (7713): 269–273. Bibcode:2018Natur.559..269H. PMID 29973723. doi:10.1038/s41586-018-0287-8.

[2] Liu Y, Lu X, Qin N, Qiao Y, Xing S, Liu W, Feng F, Liu Z, Sun H. STING, a promising target for small molecular immune modulator: A review. European Journal of Medicinal Chemistry. February 2021, 211: 113113. PMID 33360799. doi:10.1016/j.ejmech.2020.113113.

[3] Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A. The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. Nature. March 2022, 603 (7899): 145–151. Bibcode:2022Natur.603..145D. PMC 8891013 . PMID 35045565. doi:10.1038/s41586-022-04421-w.

[4] Kobritz M, Borjas T, Patel V, Coppa G, Aziz M, Wang P. H151, A Small Molecule Inhibitor of Sting as a Novel Therapeutic in Intestinal Ischemia-Reperfusion Injury. Shock. September 2022, 58 (3): 241–250. PMC 9489661 . PMID 35959789. doi:10.1097/SHK.0000000000001968.

[5] Zhao J, Xiao R, Zeng R, He E, Zhang A. Small molecules targeting cGAS-STING pathway for autoimmune disease. European Journal of Medicinal Chemistry. August 2022, 238: 114480. PMID 35635952. doi:10.1016/j.ejmech.2022.114480.

[6] Wu G, Zhang Y, Niu L, Hu Y, Yang Y, Zhao Y. Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway. Virus Research. May 2024, 343: 199344. PMC 10982080 . PMID 38431054. doi:10.1016/j.virusres.2024.199344.

[7] Tanaka M, Yasuda H, Nakamura S, Shimazawa M. H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science. July 2024, 65 (8): 16. PMC 11235146 . PMID 38980271. doi:10.1167/iovs.65.8.16.

[8] Ge X, Liu Q, Fan H, Yu H, Li J, Li Y, Qin B, Ma J, Wang J, Hu Y. STING facilitates the development of radiation-induced lung injury via regulating the PERK/eIF2α pathway. Translational Lung Cancer Research. November 2024, 13 (11): 3010–3025. PMC 11632424 . PMID 39670000. doi:10.21037/tlcr-24-649 .

[9] Xia L, Jiang JH, Liu JY, Zhang TY, Dong YX, Liu QH, Chai YF, Liu YC, Shou ST. H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway. Renal Failure. December 2024, 46 (2): 2363591. PMC 11168233 . PMID 38856314. doi:10.1080/0886022X.2024.2363591.

[10] Liu Z, Qin Q, Wang S, Kang X, Liu Y, Wei L, Lu Z, Cai W, Hu M. STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions. CNS Neuroscience & Therapeutics. December 2024, 30 (12): e70106. PMC 11656094 . PMID 39698742. doi:10.1111/cns.70106.

[11] Sun Y, Zou S, Xu X, Xu S, Sun H, Tang M, Kong W, Chen X, He Z. Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage. Neuroscience Bulletin. March 2025, 41 (3): 359–373. PMC 11876498 . PMID 39676140. doi:10.1007/s12264-024-01334-8.

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