腺苷-5'-N-乙基甲酰胺

5'-(N-Ethylcarboxamido)adenosine
	IUPAC名; (2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
别名	5'-Ethylcarboxamido adenosine; NECA
识别
CAS号	35920-39-9
PubChem	448222
ChemSpider	395094
SMILES	CCNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O;
ChEBI	73284
IUPHAR配体	377
性质
化学式	C12H16N6O4
摩尔质量	308.29 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

腺苷-5'-N-乙基甲酰胺（NECA）一种有机化合物，化学式为C₁₂H₁₆N₆O₄，它在形式上是腺苷5'位的羟甲基被乙胺羰基取代的化合物。它是一种非选择性腺苷受體興奮劑的核苷^[1]，已被用作研究腺苷受体功能的试剂。^[2]它可以2',3'-O-亚异丙基腺苷（維基數據：Q72485900）为原料经多步反应制得。^[3]

参考文献

^ Cristalli, Gloria; Lambertucci, Catia; Taffi, Sara; Vittori, Sauro; Volpini, Rosaria. Medicinal Chemistry of Adenosine A2A Receptor Agonists. Current Topics in Medicinal Chemistry. 2003, 3 (4): 387–401. doi:10.2174/1568026033392282.
^ Schwabe, U.; Lorenzen, A.; Grün, S. Adenosine receptors in the central nervous system. Recent Advances in Neuropharmacology. 1991: 149–155. ISBN 978-3-211-82300-2. doi:10.1007/978-3-7091-9175-0_19.
^ Maarten de Zwart; et al. 5‘-N-Substituted Carboxamidoadenosines as Agonists for Adenosine Receptors. J. Med. Chem. 1999, 42, 8, 1384–1392. doi:10.1021/jm9804984.

[1] Cristalli, Gloria; Lambertucci, Catia; Taffi, Sara; Vittori, Sauro; Volpini, Rosaria. Medicinal Chemistry of Adenosine A2A Receptor Agonists. Current Topics in Medicinal Chemistry. 2003, 3 (4): 387–401. doi:10.2174/1568026033392282.

[2] Schwabe, U.; Lorenzen, A.; Grün, S. Adenosine receptors in the central nervous system. Recent Advances in Neuropharmacology. 1991: 149–155. ISBN 978-3-211-82300-2. doi:10.1007/978-3-7091-9175-0_19.

[3] Maarten de Zwart; et al. 5‘-N-Substituted Carboxamidoadenosines as Agonists for Adenosine Receptors. J. Med. Chem. 1999, 42, 8, 1384–1392. doi:10.1021/jm9804984.

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