4-碘-2-甲基吡啶
| 4-碘-2-甲基吡啶 | |
|---|---|
| 识别 | |
| CAS号 | 22282-65-1 
|
| SMILES |
|
| 性质 | |
| 化学式 | C6H6IN |
| 摩尔质量 | 219.02 g·mol−1 |
| 外观 | 白色固体[1] |
| 熔点 | 42~43 °C[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
4-碘-2-甲基吡啶是一种碘代芳烃，化学式为C6H6IN。它可由4-溴-2-甲基吡啶和碘化钠在碘化亚铜和N,N'-二甲基-1,2-环己二胺催化下于1,4-二氧六环中反应制得。[1]4-三甲基锡基-2-甲基吡啶和碘反应，也能得到4-碘-2-甲基吡啶。[2]
它和三甲基硅基乙炔在催化下反应，可以得到2-甲基-4-(2-三甲基硅基乙炔基)吡啶。[3]
参考文献
[编辑]- ^ 1.0 1.1 1.2 Chen, Mao; et al. Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions. Angewandte Chemie, International Edition (2015), 54(1), 263-266. doi:10.1002/anie.201409595.
- ^ Yamamoto, Yutaka; et al. Studies on organometallic compounds. II. Facile and convenient method for the synthesis of iodoazines through iododestannation of trimethylstannylazines. Chemical & Pharmaceutical Bulletin (1982), 30(5), 1731-1737. doi:10.1248/cpb.30.1731.
- ^ Jaeschke, Georg; et al. Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of Medicinal Chemistry (2015), 58(3), 1358-1371. doi:10.1021/jm501642c.