4-五氟乙基苯甲醛
| 4-五氟乙基苯甲醛 | |
|---|---|
| 识别 | |
| CAS号 | 884602-82-8 
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| SMILES |
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| 性质 | |
| 化学式 | C9H5F5O |
| 摩尔质量 | 224.13 g·mol−1 |
| 外观 | 无色液体[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
4-五氟乙基苯甲醛是一种有机氟化合物，化学式为C9H5F5O。它可由4-碘苯甲醛和五氟乙基亚铜在二甲基甲酰胺中反应制得。[2]它和甲胺反应，可以得到相应的亚胺，经硼氢化钠还原后，可以得到N-甲基-4-五氟乙基苄胺。[3]
参考文献
[编辑]- ^ Hiroki Serizawa; et al. Direct Synthesis of Pentafluoroethyl Copper from Pentafluoropropionate as an Economical C2F5 Source: Application to Pentafluoroethylation of Arylboronic Acids and Aryl Bromides. Org. Lett. 2014, 16, 13, 3456–3459. doi:10.1021/ol501332g.
- ^ Jordi Mestre; et al. “Ligandless” Pentafluoroethylation of Unactivated (Hetero)aryl and Alkenyl Halides Enabled by the Controlled Self-Condensation of TMSCF3-Derived CuCF3. J. Org. Chem. 2019, 84, 23, 15087–15097. doi:10.1021/acs.joc.9b02001.
- ^ Mehul H. Jesani; et al. Selective Defluorination of Trifluoromethyl Substituents by Conformationally Induced Remote Substitution. Angewandte Chemie, International Edition (2024), 63(24), e202403477. doi:10.1002/anie.202403477.