鳥苷酸環化酶偶聯受體

鳥苷酸環化酶偶聯受體（guanylyl cyclase-coupled receptor^[1]）又称受體鳥苷酸環化酶（receptor guanylate cyclase^[2]）、膜结合鸟苷酸环化酶（membrane-bound guanylyl cyclase^[3]），是一種單次穿膜的細胞表面受體，属于酶偶联受体（enzyme-linked receptor）家族的成员，其可在激活後催化鸟苷三磷酸（GTP）环化为环鸟苷酸（cGMP）。

細胞表面的鳥苷酸環化酶偶聯受體一般由兩部分組成，細胞外的受體部分（胞外配体结合区）和細胞內的鳥苷酸環化酶（英语：Guanylate cyclase）部分（胞内鸟苷酸环化酶催化区）。

鳥苷酸環化酶偶聯受體的一個例子是腎臟中的心房利鈉肽（ANP）受體NRP1（英语：NRP1）、NRP2（英语：NRP2）、NRP3（英语：NRP3）。在心房感受到血流增多時，就會分泌ANP。ANP通過血液到達腎臟中的集合管（英语：Collecting duct system）時會與ANP受體結合並將之激活，產生的cGMP的生理學效應是促進鈉離子（Na⁺）在腎臟中的外排，進而促進水的外排，最終達到減少血流量的作用。另外，亦有處於細胞內的鳥苷酸環化酶偶聯受體，比如可溶性一氧化氮激活鳥苷酸環化酶（soluble NO-activated guanylate cyclase），會與細胞內的一氧化氮發生反應^[4]^[5]。

參見

cGMP

參考

^ van den Akker F, Zhang X, Miyagi M, Huo X, Misono KS, Yee VC. Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature. 2000;406(6791):101-104. doi:10.1038/35017602
^ Marks, Friedrich; Klingmüller, Ursula; Müller-Decker, Karin. Cellular Signal Processing: An Introduction to the Molecular Mechanisms of Signal Transduction. Garland Science. 2017-05-17. ISBN 978-1-351-67721-9 （英语）.
^ Tian Y, Nagel G, Gao S. An engineered membrane-bound guanylyl cyclase with light-switchable activity. BMC Biol. 2021;19(1):54. Published 2021 Mar 29. doi:10.1186/s12915-021-00978-6
^ David L. Nelson; Michael M. Cox; et al. Lehninger Priciples of Biochemistry 6th. New York: W. H. Freeman and Company. 2013: 436-484. ISBN 978-1-4292-3414-6.
^ George J. Siegel; R. Wayne Albers. Basic neurochemistry: molecular, cellular, and medical aspects. Academic Press. 2006: 368– [16 December 2010]. ISBN 978-0-12-088397-4.

[1] van den Akker F, Zhang X, Miyagi M, Huo X, Misono KS, Yee VC. Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature. 2000;406(6791):101-104. doi:10.1038/35017602

[2] Marks, Friedrich; Klingmüller, Ursula; Müller-Decker, Karin. Cellular Signal Processing: An Introduction to the Molecular Mechanisms of Signal Transduction. Garland Science. 2017-05-17. ISBN 978-1-351-67721-9 （英语）.

[3] Tian Y, Nagel G, Gao S. An engineered membrane-bound guanylyl cyclase with light-switchable activity. BMC Biol. 2021;19(1):54. Published 2021 Mar 29. doi:10.1186/s12915-021-00978-6

[Neloson2013-4] David L. Nelson; Michael M. Cox; et al. Lehninger Priciples of Biochemistry 6th. New York: W. H. Freeman and Company. 2013: 436-484. ISBN 978-1-4292-3414-6.

[SiegelAlbers2006-5] George J. Siegel; R. Wayne Albers. Basic neurochemistry: molecular, cellular, and medical aspects. Academic Press. 2006: 368– [16 December 2010]. ISBN 978-0-12-088397-4.

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