阿莫沙平
 | |
 | |
| 臨床資料 | |
|---|---|
| 读音 | A-mox-a-peen[1] |
| 商品名 | Asendin, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682202 |
| 核准狀況 | |
| 给药途径 | Oral |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
|
| 藥物動力學數據 | |
| 生物利用度 | >60%[2] |
| 血漿蛋白結合率 | 90%[3] |
| 药物代谢 | Hepatic (cytochrome P450 system)[2] |
| 生物半衰期 | 8–10 hours (30 hours for chief active metabolite)[3] |
| 排泄途徑 | Renal (60%), feces (18%)[2] |
| 识别信息 | |
| |
| CAS号 | 14028-44-5  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.034.411 |
| 化学信息 | |
| 化学式 | C17H16ClN3O |
| 摩尔质量 | 313.79 g·mol−1 |
| 3D模型（JSmol） | |
| |
| |
阿莫沙平（英語：Amoxapine，商品名有 Asendin等）是一种含氮有机氯化合物，分子式C
17H
16ClN
3O，可作为三环类抗抑郁药（TCA）[5]。
参考文献
[编辑]- ^ Amoxapine: Indications, Side Effects, Warnings -Drugs.com. Drugs.com. 6 November 2013 [26 November 2013].
- ^ 2.0 2.1 2.2 Asendin, (amoxapine) dosing, indications, interactions, adverse effects, and more. Medscape Reference. WebMD. [26 November 2013].
- ^ 3.0 3.1 Kinney JL, Evans RL. Evaluation of amoxapine. Clinical Pharmacy. September–October 1982, 1 (5): 417–424. PMID 6764165.
- ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）.
- ^ National Center for Drugs and Biologics (U.S.). Approved Prescription Drug Products with Therapeutic Equivalence Evaluations 5th, Cumulative Supplement 3. Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Food and Drug Administration. 1984: IV-9.