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新生儿Fc受体

本页使用了标题或全文手工转换
本页使用了标题或全文手工转换
维基百科，自由的百科全书
FCGRT
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名FCGRT；, FCRN, alpha-chain, Fc fragment of IgG receptor and transporter, FcgammaRn, Fc gamma receptor and transporter
外部IDOMIM：601437 MGI：103017 HomoloGene：3030 GeneCards：FCGRT
基因位置（人类）
19號染色體
染色体19號染色體[1]
19號染色體
FCGRT的基因位置
FCGRT的基因位置
基因座19q13.33起始49,506,816 bp[1]
终止49,526,428 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez

2217

14132

Ensembl

ENSG00000104870

ENSMUSG00000003420

UniProt

P55899

Q61559

mRNA​序列

NM_001136019
​NM_004107

NM_010189
​NM_001357117

蛋白序列

NP_001129491
​NP_004098

NP_034319
​NP_001344046

基因位置​（UCSC）Chr 19: 49.51 – 49.53 MbChr 7: 44.74 – 44.75 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

人新生儿可结晶片段受体（英語：Neonatal fragment crystallizable (Fc) receptor, FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor）蛋白由 FCGRT基因编码[5][6][7]。它是结构与MHC Ⅰ類分子相似并与β2-微球蛋白相关的免疫球蛋白GFc受体[8][9]。啮齿类动物的FcRn最初被确定为通过母亲的乳汁从母亲转运母体免疫球蛋白G到新生后代的受体，名称由此而来[10][11]。人类FcRn存在于胎盘并在那里转运母亲的IgG到生长中的胎儿[5][12]。FcRn还在调节IgG和血清白蛋白代谢中起作用[13][14][15][16][17]。新生儿Fc受体的表达被促炎细胞因子肿瘤坏死因子正调控，被γ-干扰素负调控[18]。

参考

[编辑]
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000104870 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000003420 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ 5.0 5.1 Story CM, Mikulska JE, Simister NE. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. The Journal of Experimental Medicine. December 1994, 180 (6): 2377–2381. PMC 2191771 可免费查阅. PMID 7964511. doi:10.1084/jem.180.6.2377. 
  6. ^ Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M, Miyosi O. The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3. Cytogenetics and Cell Genetics. July 1996, 73 (1–2): 97–98. PMID 8646894. doi:10.1159/000134316. 
  7. ^ Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha. 
  8. ^ Simister NE, Mostov KE. Cloning and expression of the neonatal rat intestinal Fc receptor, a major histocompatibility complex class I antigen homolog. Cold Spring Harbor Symposia on Quantitative Biology. 1989, 54 (Pt 1): 571–580. PMID 2534798. doi:10.1101/sqb.1989.054.01.068. 
  9. ^ Kuo TT, Aveson VG. Neonatal Fc receptor and IgG-based therapeutics. mAbs. 2011-01-01, 3 (5): 422–430. PMC 3225846 可免费查阅. PMID 22048693. doi:10.4161/mabs.3.5.16983. 
  10. ^ Rodewald R, Kraehenbuhl JP. Receptor-mediated transport of IgG. The Journal of Cell Biology. July 1984, 99 (1 Pt 2): 159s–164s. PMC 2275593 可免费查阅. PMID 6235233. doi:10.1083/jcb.99.1.159s. 
  11. ^ Simister NE, Rees AR. Isolation and characterization of an Fc receptor from neonatal rat small intestine. European Journal of Immunology. July 1985, 15 (7): 733–738. PMID 2988974. S2CID 42396197. doi:10.1002/eji.1830150718. 
  12. ^ Firan M, Bawdon R, Radu C, Ober RJ, Eaken D, Antohe F, et al. The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. International Immunology. August 2001, 13 (8): 993–1002. PMID 11470769. doi:10.1093/intimm/13.8.993 可免费查阅. 
  13. ^ Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. European Journal of Immunology. March 1996, 26 (3): 690–696. PMID 8605939. S2CID 85730132. doi:10.1002/eji.1830260327 可免费查阅. 
  14. ^ 引用错误：没有为名为pmid12566415的参考文献提供内容
  15. ^ 引用错误：没有为名为:11的参考文献提供内容
  16. ^ Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nature Reviews. Immunology. September 2007, 7 (9): 715–725. PMID 17703228. S2CID 6980400. doi:10.1038/nri2155 （英语）. 
  17. ^ Ward ES, Ober RJ. Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn. Advances in Immunology 103. 2009: 77–115. ISBN 978-0-12-374832-4. PMC 4485553 可免费查阅. PMID 19755184. doi:10.1016/S0065-2776(09)03004-1. 
  18. ^ 引用错误：没有为名为:02的参考文献提供内容
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