年輕血液輸入

年輕血液輸入 (英語：Young blood transfusion) 是指較老年的人輸入輸入從較年輕的人捐出的血液，以達到更健康或抗衰老的效果。^[1]輸入年輕人的血液，在效果和安全性都備受爭議，只有非常有限的臨床證據證明其效用。^[1]^[2]^[3]輸入年輕人的血液也會帶來健康上的傷害。^[3] 雖然有些動物實驗的證據證明有用，但沒有臨床證實證明人類有同樣的效果。^[4]^[5]^[6]^[7]^[8]^[9]在2019年美國食品及藥物管理局警告，消費者不要接受年輕捐贈者的血液輸入，稱這是一種未經證實的治療方法。^[3]

參考文獻

^ ^1.0 ^1.1 Novella S. Parabiosis – The Next Snakeoil. Science-Based Medicine. 3 August 2016 [2025-04-30]. （原始内容存档于2020-04-15）.
^ Robbins R. Young-Blood Transfusions Are on the Menu at Society Gala. Scientific American. March 2, 2018 [26 May 2018]. （原始内容存档于2019-12-06）（英语）.
^ ^3.0 ^3.1 ^3.2 Statement from FDA Commissioner Scott Gottlieb, M.D., and Director of FDA's Center for Biologics Evaluation and Research Peter Marks, M.D., Ph.D., cautioning consumers against receiving young donor plasma infusions that are promoted as unproven treatment for varying conditions. FDA. 19 February 2019 [20 February 2019]. （原始内容存档于2019-04-23）.
^ Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. February 2005, 433 (7027): 760–764. Bibcode:2005Natur.433..760C. PMID 15716955. doi:10.1038/nature03260.
^ Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. May 2014, 344 (6184): 649–652. Bibcode:2014Sci...344..649S. PMC 4104429 . PMID 24797481. doi:10.1126/science.1251152.
^ Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. June 2014, 20 (6): 659–663. PMC 4224436 . PMID 24793238. doi:10.1038/nm.3569.
^ Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. May 2014, 344 (6184): 630–634. Bibcode:2014Sci...344..630K. PMC 4123747 . PMID 24797482. doi:10.1126/science.1251141.
^ Mccay CM, Pope F, Lunsford W, Sperling G, Sambhavaphol P. Parabiosis between old and young rats. Gerontologia. 1957, 1 (1): 7–17. PMID 13405201. doi:10.1159/000210677.
^ Horvath S, Singh K, Raj K, Khairnar SI, Sanghavi A, Shrivastava A, Zoller JA, Li CZ, Herenu CB, Canatelli-Mallat M, Lehmann M, Habazin S, Novokmet M, Vučković F, Solberg Woods LC, Martinez AG, Wang T, Chiavellini P, Levine AJ, Chen H, Brooke RT, Gordevicius J, Lauc G, Goya RG, Katcher HL. Reversal of biological age in multiple rat organs by young porcine plasma fraction. GeroScience. February 2024, 46 (1): 367–394. PMC 10828479 . PMID 37875652. doi:10.1007/s11357-023-00980-6.

參見

[sbm-1] 1.0 ^1.1 Novella S. Parabiosis – The Next Snakeoil. Science-Based Medicine. 3 August 2016 [2025-04-30]. （原始内容存档于2020-04-15）.

[sciam-2] Robbins R. Young-Blood Transfusions Are on the Menu at Society Gala. Scientific American. March 2, 2018 [26 May 2018]. （原始内容存档于2019-12-06）（英语）.

[FDA2019-3] 3.0 ^3.1 ^3.2 Statement from FDA Commissioner Scott Gottlieb, M.D., and Director of FDA's Center for Biologics Evaluation and Research Peter Marks, M.D., Ph.D., cautioning consumers against receiving young donor plasma infusions that are promoted as unproven treatment for varying conditions. FDA. 19 February 2019 [20 February 2019]. （原始内容存档于2019-04-23）.

[4] Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. February 2005, 433 (7027): 760–764. Bibcode:2005Natur.433..760C. PMID 15716955. doi:10.1038/nature03260.

[5] Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. May 2014, 344 (6184): 649–652. Bibcode:2014Sci...344..649S. PMC 4104429 . PMID 24797481. doi:10.1126/science.1251152.

[6] Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. June 2014, 20 (6): 659–663. PMC 4224436 . PMID 24793238. doi:10.1038/nm.3569.

[7] Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. May 2014, 344 (6184): 630–634. Bibcode:2014Sci...344..630K. PMC 4123747 . PMID 24797482. doi:10.1126/science.1251141.

[8] Mccay CM, Pope F, Lunsford W, Sperling G, Sambhavaphol P. Parabiosis between old and young rats. Gerontologia. 1957, 1 (1): 7–17. PMID 13405201. doi:10.1159/000210677.

[9] Horvath S, Singh K, Raj K, Khairnar SI, Sanghavi A, Shrivastava A, Zoller JA, Li CZ, Herenu CB, Canatelli-Mallat M, Lehmann M, Habazin S, Novokmet M, Vučković F, Solberg Woods LC, Martinez AG, Wang T, Chiavellini P, Levine AJ, Chen H, Brooke RT, Gordevicius J, Lauc G, Goya RG, Katcher HL. Reversal of biological age in multiple rat organs by young porcine plasma fraction. GeroScience. February 2024, 46 (1): 367–394. PMC 10828479 . PMID 37875652. doi:10.1007/s11357-023-00980-6.

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