二茂铁氯喹

二茂铁氯喹
识别信息
	IUPAC命名法 7-chloro-N-(2-((dimethylamino)methyl)ferrocenyl)quinolin-4-amine; ;
CAS号	185055-67-8
PubChem CID	140118553;
UNII	8D81JS19ET;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID00939922 ;
ECHA InfoCard	100.208.008
化学信息
化学式	C23H24ClFeN3
摩尔质量	433.76 g·mol−1
	InChI InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2; Key:DDENDDKMBDTHAX-UHFFFAOYSA-N;

二茂铁氯喹是一种有机化合物，化学式为C₂₃H₂₄ClFeN₃，最早于1997年被报道。^[1]它具有抗疟作用，对氯喹耐药菌株有良好的活性。^[2]它具有二茂铁环，这种有机金属组分在药物中并不常见。^[3]^[4]^[5]

它的喹啉环上的氮可以和金或铑配位，得到相应的配合物。^[6]

参考文献

^ Biot C, Glorian G, Maciejewski LA, Brocard JS. Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. Journal of Medicinal Chemistry. November 1997, 40 (23): 3715–3718. PMID 9371235. doi:10.1021/jm970401y.
^ Domarle O, Blampain G, Agnaniet H, Nzadiyabi T, Lebibi J, Brocard J, et al. In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine. Antimicrobial Agents and Chemotherapy. March 1998, 42 (3): 540–544. PMC 105495 . PMID 9517929. doi:10.1128/AAC.42.3.540.
^ Dive D, Biot C. Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial. ChemMedChem. March 2008, 3 (3): 383–391. PMC 7162372 . PMID 17806092. doi:10.1002/cmdc.200700127.
^ Biot C, Nosten F, Fraisse L, Ter-Minassian D, Khalife J, Dive D. The antimalarial ferroquine: from bench to clinic. Parasite. August 2011, 18 (3): 207–214. PMC 3671469 . PMID 21894260. doi:10.1051/parasite/2011183207.
^ Wani WA, Jameel E, Baig U, Mumtazuddin S, Hun LT. Ferroquine and its derivatives: new generation of antimalarial agents. European Journal of Medicinal Chemistry. August 2015, 101: 534–551. PMC 7115395 . PMID 26188909. doi:10.1016/j.ejmech.2015.07.009.
^ Blackie, Margaret A. L.; et al. Synthesis and antimalarial activity in vitro of new heterobimetallic complexes: Rh and Au derivatives of chloroquine and a series of ferrocenyl-4-amino-7-chloroquinolines. Journal of Organometallic Chemistry (2003), 688(1-2), 144-152. doi:10.1016/j.jorganchem.2003.07.026.

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[1] Biot C, Glorian G, Maciejewski LA, Brocard JS. Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. Journal of Medicinal Chemistry. November 1997, 40 (23): 3715–3718. PMID 9371235. doi:10.1021/jm970401y.

[2] Domarle O, Blampain G, Agnaniet H, Nzadiyabi T, Lebibi J, Brocard J, et al. In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine. Antimicrobial Agents and Chemotherapy. March 1998, 42 (3): 540–544. PMC 105495 . PMID 9517929. doi:10.1128/AAC.42.3.540.

[3] Dive D, Biot C. Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial. ChemMedChem. March 2008, 3 (3): 383–391. PMC 7162372 . PMID 17806092. doi:10.1002/cmdc.200700127.

[4] Biot C, Nosten F, Fraisse L, Ter-Minassian D, Khalife J, Dive D. The antimalarial ferroquine: from bench to clinic. Parasite. August 2011, 18 (3): 207–214. PMC 3671469 . PMID 21894260. doi:10.1051/parasite/2011183207.

[5] Wani WA, Jameel E, Baig U, Mumtazuddin S, Hun LT. Ferroquine and its derivatives: new generation of antimalarial agents. European Journal of Medicinal Chemistry. August 2015, 101: 534–551. PMC 7115395 . PMID 26188909. doi:10.1016/j.ejmech.2015.07.009.

[6] Blackie, Margaret A. L.; et al. Synthesis and antimalarial activity in vitro of new heterobimetallic complexes: Rh and Au derivatives of chloroquine and a series of ferrocenyl-4-amino-7-chloroquinolines. Journal of Organometallic Chemistry (2003), 688(1-2), 144-152. doi:10.1016/j.jorganchem.2003.07.026.

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