丹参素
| 丹参素 | |
|---|---|
lactic_acid.svg)
| |
| IUPAC名 (2R)-3-(3,4-Dihydroxyphenyl)lactic acid | |
| 识别 | |
| CAS号 | 76822-21-4 67920-52-9 |
| PubChem | 11600642 23711819 |
| ChemSpider | 9775399 |
| SMILES |
|
| EINECS | 804-698-5 |
| ChEBI | 71572 |
| KEGG | C22038 |
| 性质 | |
| 化学式 | C9H10O5 |
| 摩尔质量 | 198.17 g·mol−1 |
| 熔点 | 84-86℃ [1] |
| 相关物质 | |
| 相关化学品 | 原儿茶酸 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
丹参素（英語：Danshensu 或称为丹参酸甲、丹参酸A Salvianic acid A）是一种α-羟基酸，存在于植物丹参和香蜂花中，是一些传统中药的活性成分[2]。
丹参素是在丹参根的水溶性提取物中发现的[3][4]，可溶于水、甲醇、乙醇、乙酸乙酯和丙酮[4]。而丹参的脂溶性提取物为丹参酮。
反应
[编辑]丹参素对空气及碱性条件敏感，暴露时会氧化、聚合并变暗。丹参素经硫酸二甲酯处理后，其羟基可被甲基化。在酸性条件下，丹参素可转化为丹酚酸C（Salvianolic acid C）[4]。
药理学
[编辑]丹参素可扩张心脏动脉[5]。
丹参素直接与糖酵解酶PKM2结合，导致内皮糖酵解急剧下降，并以PKM2依赖的方式激活β-Catenin/Claudin-5信号轴来改善内皮完整性，从而诱导肿瘤血管正常化[6]。
参考文献
[编辑]- ^ Zhou, Jiaju; Xie, Guirong; Yan, Xinjian. Encyclopedia of Traditional Chinese Medicines - Molecular Structures, Pharmacological Activities, Natural Sources and Applications: Vol. 2: Isolated Compounds D-G. Springer Science & Business Media. 2011-02-11: 6–7. ISBN 978-3-642-16738-6 （英语）.
- ^ Cao, Hong-Ying; Ding, Rui-Lin; Li, Meng; Yang, Mao-Nan; Yang, Ling-Lin; Wu, Jing-Bo; Yang, Bo; Wang, Jing; Luo, Cui-Lian; Wen, Qing-Lian. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice. Oncology Letters. February 2017, 13 (2): 605–612. PMC 5351344
. PMID 28356936. doi:10.3892/ol.2016.5508.
- ^ Lian-niang, Li; Rui, Tan; Wei-ming, Chen. Salvianolic Acid A, a New Depside from Roots of Salvia miltiorrhiza. Planta Medica. June 1984, 50 (3): 227–228. PMID 17340301. S2CID 10164834. doi:10.1055/s-2007-969684.
- ^ 4.0 4.1 4.2 Li, Lianniang. Water Soluble Components of Danshen. Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 1. Biology and Chemistry. Springer Netherlands. 2015: 97–117. ISBN 978-94-017-9469-5. doi:10.1007/978-94-017-9469-5_7 （英语）.
- ^ Liu, Guang; Zhang, Qianqian; Zhang, Jinli; Zhang, Ning. Preventive but nontherapeutic effect of danshensu on hypoxic pulmonary hypertension. Journal of International Medical Research. 2020-05, 48 (5): 030006052091421. PMC 7235679 . PMID 32419546. doi:10.1177/0300060520914218.
- ^ Cheng Qian, Yueke Zhou, Teng Zhang, Guanglu Dong, Mengyao Song, Yu Tang, Zhonghong Wei, Suyun Yu, Qiuhong Shen, Wenxing Chen, Jaesung P. Choi, Juming Yan, Chongjin Zhong, Li Wan, Jia Li, Aiyun Wang, Yin Lu, Yang Zhao. Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery. Acta Pharmaceutica Sinica B. 2024-05, 14 (5): 2077–2096. PMC 11121179 . PMID 38799619. doi:10.1016/j.apsb.2024.02.003.
参见
[编辑]延伸阅读
[编辑]- Yan, Xijun. Dan Shen (Salvia miltiorrhiza) in Medicine: Volume 2. Pharmacology and Quality Control. Springer. 27 October 2014. ISBN 978-94-017-9463-3 （英语）.